CYTOSINE

作品数：68被引量：93H指数：6
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相关机构：重庆医科大学附属第二医院广州科技贸易职业学院大连海洋大学浙江工业大学更多>>
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Diverse nucleotide substitutions in rice base editing mediated by novel TadA variants
《Plant Communications》2024年第8期104-112,共9页Man Yu Yongjie Kuang Chenyang Wang Xuemei Wu Shaofang Li Dawei Zhang Wenxian Sun Xueping Zhou Bin Ren Huanbin Zhou 
supported by the STI 2030-Major Projects(2023ZD04074);the National Key Research and Development Program of China(2023YFD1202900);the Nanfan special project of the Chinese Academy of Agricultural Sciences(YBXM2313);the Hainan Seed Industry Laboratory(project of B23CJ0208);the Agricultural Science and Technology Innovation Program of the Chinese Academy of Agricultural Sciences.
CRISPR-mediated base editors have been widely used to correct defective alleles and create novel alleles by artificial evolution for the rapid genetic improvement of crops.The editing capabilities of base editors stri...
关键词：CRISPR TadA variants cytosine base editing dual base editor RICE 
Reduced non-CpG methylation is a potential epigenetic target after spinal cord injury
《Neural Regeneration Research》2023年第11期2489-2496,共8页Zhourui Wu Chen Li Ran Zhu Yiqiu Cao Thomas C.Chen Liming Cheng 
National Key Research and Development Program of China,No.2016YFA0100800(to LC);International(Regional)Cooperation and Communication Program of the National Natural Science Foundation of China,No.81820108013(to LC);State Key Program of the National Natural Science Foundation of China,No.81330030(to LC);National Natural Science Foundation of China,Nos.82071370(to ZW),81301042(to LC);Shanghai Pujiang Program,No.19PJ1409200(to ZW);Shanghai Sailing Program,No.21YF1442400(to CL)。
DNA methylation is a critical epigenetic regulator in the occurrence and development of diseases and is closely related to various functional responses in relation to spinal cord injury.To investigate the role of DNA ...
关键词：CpG methylation cytosine fraction differentially methylated regions DNA methylation DNA methyltransferases dynamic signatures Gene Ontology non-CpG methylation single-cell RNA-Seq spinal cord injury 
Bisulfite-free mapping of DNA cytosine modifications:challenges and perspectives
《Science China Chemistry》2023年第11期3044-3053,共10页Yanfang Du Ying Tang Bingqian Lin Xiaochen Xue Yafen Wang Yibin Liu 
supported by the start-up funding from Wuhan University;Fundamental Research Funds for the Central Universities(2042023kf0118)。
The mapping of DNA cytosine modifications is crucial for understanding the dynamic landscape of epigenetic regulation.While bisulfite sequencing has been the gold standard for decades,it suffers from limitations such ...
关键词：bisulfite-free cytosine modifications DNA sequencing base-resolution 
Artificial evolution of OsEPSPS through an improved dual cytosine and adenine base editor generated a novel allele conferring rice glyphosate tolerance被引量：6
《Journal of Integrative Plant Biology》2023年第9期2194-2203,共10页Chen Zhang Xue Zhong Shaoya Li Lei Yan Jingying Li Yubing He Yong Lin Yangjun Zhang Lanqin Xia 
partly funded by the National Natural Science Foundation of China (32188102 to LX);Hainan Yazhou Bay Seed Lab (B21HJ0215 to LX);the Central Public-Interest Scientific Institution-Based Research Fund (S2023ZD03 to LX);Key Laboratory of Gene Editing Technologies (Hainan), China;National Engineering Research Center of Crop Molecular Breeding。
Exploiting novel endogenous glyphosate-tolerant alleles is highly desirable and has promising potential for weed control in rice breeding. Here,through fusions of different effective cytosine and adenine deaminases wi...
关键词：artificial evolution dual cytosine and adenine base editor nCas9‐NG rice(Oryza sativa L) near‐saturated mutagenesis 
Human 8-cell embryos enable efficient induction of disease-preventive mutations without off-target effect by cytosine base editor
《Protein & Cell》2023年第6期416-432,共17页Yinghui Wei Meiling Zhang Jing Hu Yingsi Zhou Mingxing Xue Jianhang Yin Yuanhua Liu Hu Feng Ling Zhou Zhifang Li Dongshuang Wang Zhiguo Zhang Yin Zhou Hongbin Liu Ning Yao Erwei Zuo Jiazhi Hu Yanzhi Du Wen Li Chunlong Xu Hui Yang 
supported by Chinese National Science and Technology major project R&D Program of China(2018YFC2000101);Strategic Priority Research Program of Chinese Academy of Science(XDB32060000);National Natural Science Foundation of China(Grant Nos.31871502,31901047,31925016,91957122,82021001,and 31922048);Basic Frontier Scientific Research Program of Chinese Academy of Sciences From 0 to 1 original innovation project(ZDBS-LYSM001);Shanghai Municipal Science and Technology Major Project(2018SHZDZX05);Shanghai City Committee of Science and Technology Project(18411953700,18JC1410100,19XD1424400 and 19YF1455100);Innovative Research Team of High-Level Local Universities in Shanghai(SHSMU-ZDCX20212200 and SHSMU-ZLCX20210200);International Partnership Program of Chinese Academy of Sciences(153D31KYSB20170059);Postdoctoral Science Foundation of China(2020M681417 and 2021T140684);Sailing Program of Shanghai(21YF1453000)(to J.H.).
Approximately 140 million people worldwide are homozygous carriers of APOE4(ε4),a strong genetic risk factor for late onset familial and sporadic Alzheimer’s disease(AD),91%of whom will develop AD at earlier age tha...
关键词：human embryo APOE4 disease-preventive mutations base editor 
DNA methylation in the genesis,progress and prognosis of head and neck cancer
《Holistic Integrative Oncology》2023年第1期200-212,共13页Zijian Guo Wenwen Liu Yuhan Yang Shunhao Zhang Chunjie Li Wenbin Yang 
supported by the Sichuan University-Panzhihua City 2021 Campus Cooperation Special Fund Project[grant number 2021CDPZH-7].
Epigenetic alteration studies in cancer research have been progressing rapidly in recent years.DNA methylation,including DNA hypermethylation and DNA hypomethylation,is one of the main epigenetic alterations in head a...
关键词：Head and Neck Cancer(HNC) DNA Methylation DNA(Cytosine-5-)-Methyltransferases(DNMT) Ten-Eleven Translocation(TET) CARCINOGENESIS 
Precise genome editing with base editors
《Medical Review》2023年第1期75-84,共10页Hongcai Liu Yao Zhu Minjie Li Zhimin Gu 
supported by CAMS Innovation Fund for Medical Sciences(CIFMS,2022-I2M-1-024,2022-RC180-02 to Z.G.).
Single-nucleotide variants account for about half of known pathogenic genetic variants in human.Genome editing strategies by reversing pathogenic point mutations with minimum side effects have great therapeutic potent...
关键词：adenine base editor base editing clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein cytosine base editor 
Facile Synthesis of a Novel Bio-Based P-N Containing Flame Retardant for Effectively Reducing the Fire Hazards of Epoxy Resin
《Journal of Renewable Materials》2022年第10期2639-2654,共16页Meixian Li Xin Hu Jie Yang Hongyu Yang Yao Yuan 
the financial supports from Fundamental Research Funds for the Central Universities(2020CDJQY-A006);the National Natural Science Foundation of China(No.51603025);The Opening Fund of State Key Laboratory of Fire Science(HZ2019-KF11).
In this work,a bio-based flame retardant(Cy-HEDP)was synthesized from cytosine and HEDP through a facile salt-forming reaction and embedded into epoxy matrix to improve the flame retardancy and smoke suppression perfo...
关键词：Bio-based materials CYTOSINE smoke suppression flame retardant epoxy resin 
Collision site effect on the radiation dynamics of cytosine induced by proton
《Chinese Physics B》2022年第6期316-325,共10页Xu Wang Zhi-Ping Wang Feng-Shou Zhang Chao-Yi Qian 
supported by the National Natural Science Foundation of China(Grant Nos.11905160 and 11635003);the‘333’Project of Jiangsu Province,China(Grant No.BRA2020327);the Science Foundation of Wuxi Institute of Technology(Grant No.ZK201903)。
By combing the time-dependent density functional calculations for electrons with molecular dynamics simulations for ions(TDDFT-MD)nonadiabatically in real time,we investigate the microscopic mechanism of collisions be...
关键词：time-dependent density functional theory CYTOSINE proton-induced collision FRAGMENTATION 
PtRu nanoparticles supported on noble carbons for ethanol electrooxidation
《Journal of Energy Chemistry》2022年第3期168-180,I0006,共14页Alberto Rodríguez-Gómez Enrico Lepre Luz Sánchez-Silva Nieves López-Salas Ana Raquel de la Osa 
the Spanish Ministry of Science and Innovation(State Research Agency.Project PID2019-107499RB100)for the financial support;The Max Planck Society。
In this work,three cytosine derived nitrogen doped carbonaceous materials(noble carbons,NCs)with different atomic C/N ratios and porous networks have been synthesized and used as supports for Pt Ru electrocatalysts in...
关键词：Noble carbon CYTOSINE H2 production Ethanol electrooxidation PtRu anode PEM cell 
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