The work was supported by the Anhui Provincial Natural Science Foundation(1608085QH172);States S&T Projects of 13th Five Year(2018ZX10302206),Chinese Founda-tion for Hepatitis Prevention and Control(TQGB20200151,TQGB20180367);Anhui Key Program of Medical Scien-tific Research of China(#2010A010).
Background and Aims:Ras-related nuclear(RAN)protein is a small GTP-binding protein that is indispensable for the translocation of RNA and proteins through the nuclear pore complex.Recent studies have indicated that RA...
This work was supported by the Strategic Priority Research Program of CAS(XDB29010000);the National Science and Technology Major Project(2018ZX10101004 and 2018ZX10733403);the National Key Research and Development Program of China(2020YFC0845900,2016YFD0500300 and 2016YFE0205800);the National Natural Science Foundation of China(82041016,81871658,81673358 and 21807109);a grant from the Bill&Melinda Gates Foundation and and is partially supported by the Yanqi Lake Meeting organized by the Academic Divisions of CAS;Y.S.is supported by the Youth Innovation Promotion Association of CAS.
Dear Editor,The second wave of the coronavirus disease(COVID-19)pandemic has recently appeared in Europe.Most European countries,such as France,Germany,and Italy,have announced the implementation of a new round of epi...
supported by the CEMB-TWAS Postgraduate Fellowship(FR number 3240286682,2015)granted to Mr.Koloko Brice Landry
Objective:To evaluate the antiviral activity and phytochemicals of selected plant extracts and their effect on the mitogen-activated protein kinase(MAPK)signaling pathway modulated by hepatitis C virus(HCV)nonstructur...
supported by the National Science and Technology Major Project of China in the 13th Five-Year(2017ZX10201101-002-003)
The aim of this study was to evaluate the performance of an assay using dried plasma spot(DPS)and dried blood spot(DBS)samples for the serological detection of anti-hepatitis C virus(HCV)antibodies.Between January and...
supported by the National Natural Science Foundation of China (Nos. 21472246 and 81321004);the Beijing Natural Science Foundation (No. 7152097);National Mega-Project for Innovation Drugs (No. 2012ZX09103101-037)
A new series of 12-benzyl matrinic amide/ethanamide derivatives were synthesized from matrinine(1)and evaluated for their anti-HCV activity,taking compound 2 as the lead.SAR revealed that the introduction of a suita...
Unlike human immunodeficiency virus(HIV)and hepatitis B virus(HBV),hepatitis C virus(HCV)infection is a curable disease.Current direct antiviral agent(DAA)targets are focused on HCV NS3/4A protein(protease),NS5 B prot...