Frequency and Absolute Number of FoxP3^+ Regulatory T Cells Correlate with Disease Progression of Chronic HIV-1 Infection  

作　　者：Jun-liang FU Fu-biao KANG Yan-mei JIAO Shao-jun XING Bao-yun FU Chun-bao ZHOU Xi-cheng WANG Hao WU Fu-Sheng WANG 

机构地区：[1]Research Center of Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China [2]Postgraduate Team, Military Postgraduate Medical College,Beijing 100853, China [3]Department of Infectious Diseases, Beijing You-An Hospital Affiliated to Capital University of Medical Science, Beijing 100054, China

出　　处：《Virologica Sinica》2007年第6期501-508,共8页中国病毒学（英文版）

基　　金：The National Outstanding Youth Foundation of China (30525042);National 973 project of China (2006CB504201,2006CB504205)

摘　　要：CD4^＋CD25^＋ Regulatory T cells （Treg） have been found to down-regulate immune activation in HIV-1 infection. However, whether the depletion of Treg benefits to the disease status of HIV infection remains undefined. To address this issue, we enumerated the Treg absolute counts and frequency in 75 antiviral-naive HIV-1-infected individuals in this study. It was found that HIV-infected patients displayed a significant decline in Treg absolute counts but a significant increase in Treg frequency. In addition, with disease progression indicated by CD4 T-cell absolute counts, circulating Treg frequency gradually increased; while Treg absolute counts were gradually decreased, suggesting that the alteration of Treg number closely correlated with disease progression in HIV infection Functional analysis further showed that Treg efficiently inhibit both CD4 and CD8 T cell proliferation in vitro. Thus, our findings indicates that Treg actively participate in pathogenesis of chronic HIV infection, influencing the disease progression.CD4+CD25+ Regulatory T cells (Treg) have been found to down-regulate immune activation in HIV-1 infection. However,whether the depletion of Treg benefits to the disease status of HIV infection remains undefined. To address this issue,we enumerated the Treg absolute counts and frequency in 75 antiviral-nave HIV-1-infected individuals in this study. It was found that HIV-infected patients displayed a significant decline in Treg absolute counts but a significant increase in Treg frequency. In addition,with disease progression indicated by CD4 T-cell absolute counts,circulating Treg frequency gradually increased; while Treg absolute counts were gradually decreased,suggesting that the alteration of Treg number closely correlated with disease progression in HIV infection. Functional analysis further showed that Treg efficiently inhibit both CD4 and CD8 T cell proliferation in vitro. Thus,our findings indicates that Treg actively participate in pathogenesis of chronic HIV infection,influencing the disease progression.

关 键 词：T-LYMPHOCYTES HIV Infections Tolerance/Suppression/Anergy Proliferation 

分 类 号：R512.91[医药卫生—内科学]