猪去氧胆酸-β-环糊精包合物的制备  

Preparation of α-Hydrocycholic-β-Cyclodextrin Inclusion Compound

作　　者：卞艳红[1] 张丹雁[2] 熊清平[3] 

机构地区：[1]淮安市第二人民医院药剂科,江苏淮安223002 [2]广州中医药大学中药学院,广东广州510405 [3]淮阴工学院生化学院,江苏淮安223003

出　　处：《中药材》2007年第11期1452-1455,共4页Journal of Chinese Medicinal Materials

摘　　要：目的:研究猪去氧胆酸-β-环糊精包合物的制备工艺条件。方法:运用正交实验法,对影响β-环糊精包合物猪去氧胆酸的3个主要因素——包合时间、β-环糊精与猪去氧胆酸的比例、包合温度进行极差分析和方差分析。采用傅立叶变换红外光谱法、电镜扫描法、口感验证法以及溶解度测定法对制备的包合物进行鉴定。结果:猪去氧胆酸经β-环糊精已形成稳定的包合物,β-环糊精与猪去氧胆酸的比例对包合物的制备影响显著,猪去氧胆酸经β-环糊精包合后口感和溶解度均有明显改善。结论:猪去氧胆酸-β-环糊精包合物的制备工艺条件为:包合时间30 min,β-环糊精与猪去氧胆酸的比例为5.78∶1,包合温度60℃。Objective： To study the preparation of α-Hydrocycholic-β-Cyclodextrin inclusion compound.Methods： It was studied with orthogonal design to analysis three factors of inclusion rate such as the weight ratio between HDCA and β-Cyclodextrin,the temperature and the reaction time.Fourier transform infrared spectroscopy,scanning electron microscopy,taste and solubility test were used to identify the inclusion compound.Results： Stable inclusion compound was made by HDCA and β-Cyclodextrin.The weight ratio between HDCA and β-Cyclodextrin was the most important factor.The α-Hydrocycholic-β-Cyclodextrin inclusion compound taste and the solubility were improved.Conclusion： The optimum preparation condition is α-Hydrocycholic：β-Cyclodextrin=8.67∶1,the inclusion temperature is 60℃ and the inclusion time is 30 minutes.

关 键 词：猪去氧胆酸 Β-环糊精 正交实验 制备工艺 

分 类 号：R284.2[医药卫生—中药学]