建立信息化的中医和针灸临床研究:孟德尔遗传定律的发现过程给我们的启示  

Building a Bioinformatics Platform for Clinical Research of Traditional Chinese Medicine and Acupuncture:Lessons Learnt from the Greatest Geneticist of Our Time,Gregor J.Mendel

作　　者：夏月[1] 

机构地区：[1]美国国家卫生部健康科学研究院过敏和感染疾病研究所,马里兰208927612

出　　处：《针刺研究》2007年第6期393-398,共6页Acupuncture Research

摘　　要：中医和针灸理论是中国古人在观察人的基本生理病理机制和治疗人类疾病的实践中提炼出的朴素的医学理论,它是在中国古代哲学和原始的医学实践相融合的基础上而形成的。现代针灸研究表明,古老的中医针灸理论中积累了许多经得起现代医学检验的临床实践。近年来,现代生物信息学把现代生物医学推向了基因组和后基因组的时代;计算机在生物学中的应用,大大地拓展了生物医学研究的深度和广度;一系列以数学模式和统计学为基础的、新的数据分析方法,使现代生物医学的亮点从分析局部效应走向系统整合,提高了科学研究结果在临床实际中的应用性和可重复性。这些新的生物信息学方法,可以帮助中医针灸在保持其特色的前提下,引入新的以数学为基础的数据分析方法,扩大临床研究样本的积累,提高研究效率和数据整合。Traditional Chinese Medicine （TCM） and acupuncture are ancient medical theories that combine the experience of clinical practice of TCM and acupuncture with ancient Chinese philosophy. Although basic and clinical researches have been carried out to explore the effectiveness and possible mechanisms of TOM and acupuncture treatment, many aspects of TOM and acupuncture in daily patient care still need to be optimized under the framework of TOM and acupuncture. The greatest geneticist Gregor J. Mendel had shown us that great science like Mendel＇s Law can be developed with a careful planning of a large sample collection, accurate observation, data recording, innovative data analysis and mathematic modeling. Learning from Mendel, TOM and acupuncture can take advantage of bioinformatics in genomic and post-genomic era to advance TOM and acupuncture according to their own theories. In recent years, many new data mining and statistical analysis methods developed with bioinformatics platforms provide tools for scientists to investigate diseases and treatments using less of a reductionism approach and more of a systemic approach. Bioinformatics can provide an effective platform to improve the accuracy of data collection in TCM and acu- puncture clinic. It can facilitate large sample collections and provide computational tools for data mining and statistical analysis. It is a systems approach to advance TOM and acupuncture in genomic and post genomic era.

关 键 词：针灸 孟德尔定律 数据分析方法 信息平台 临床数据收集 

分 类 号：R2-03[医药卫生—中医学]