TFPI-2与VEGF在胰腺癌中的表达  

Expression of TFPI-2 and VEGF in Pancreatic Carcinoma Angiogenesis

作　　者：孙振阳[1] 汤志刚[1] 胡何节[1] 许戈良[1] 陈炯[1] 李建生[1] 

机构地区：[1]安徽医科大学附属安徽省立医院普通外科,合肥市230001

出　　处：《中国肿瘤临床》2007年第23期1327-1329,共3页Chinese Journal of Clinical Oncology

基　　金：安徽省自然科学基金资助(编号:050430702)

摘　　要：目的:探讨胰腺癌中TFPI-2表达对胰腺癌肿瘤血管生成的影响。方法:采用免疫组织化学方法检测41例胰腺癌组织中TFPI-2、VEGF的表达及CD34单克隆抗体标记的微血管密度(MVD)。结果:Ⅰ、Ⅱ期胰腺癌及无远处转移的胰腺癌组织中TFPI-2阳性表达率分别为65.4%和57.1%,Ⅲ、Ⅳ期及有远处转移的胰腺癌组织中的TFPI-2阳性表达率分别为13.3%和23.1%,TFPI-2表达率,Ⅰ、Ⅱ期高于Ⅲ、Ⅳ期,无远处转移高于有远处转移,差异有统计学意义(P<0.05);VEGF阳性表达率在Ⅰ、Ⅱ期及无远处转移的胰腺癌组织分别为23.0%和32.1%,在Ⅲ、Ⅳ期及有远处转移的胰腺癌组织分别为66.7%和61.5%,两者比较,差异有统计学意义(P<0.05);Ⅲ、Ⅳ期及有远处转移的胰腺癌组织MVD值分别为28.47±2.23和19.00±2.58,高于Ⅰ、Ⅱ期的26.92±1.06及无远处转移的16.68±1.79,差异有统计学意义(P<0.05);胰腺癌组织中的TFPI-2的表达与VEGF的表达呈负相关(r=-0.54),差异有统计学意义(P<0.05);MVD与TFPI-2表达有关,TFPI-2阳性表达的胰腺癌组织MVD值为33.33±3.23,低于TFPI-2阴性表达的胰腺癌组织36.00±3.17,两者比较,差异有统计学意义(P<0.05)。结论:胰腺癌中TFPI-2可能通过下调VEGF的表达抑制肿瘤新生血管的形成,从而抑制胰腺癌的生长、转移。Objective： To explore the effect of tissue factor pathway inhibitor-2 （TFPI-2） expression on the angiogenesis of pancreatic carcinoma. Methods： hnmunohistoehemistry was employed to detect the expression of TFPI-2 and VEGF and MVD was assessed with CD34 in 41 eases of pancreatic carcinoma. Results： The expression rate of TFPI-2 in pancreatic earcinoma of stage Ⅰ and Ⅱ was 65.4%, higher than that of stage Ⅲ and Ⅳ （13.3%）, with a significant difference （P〈0.05）. The expression rate of TFPI-2 in pancreatic carcinoma without distant metastasis was 57.1%, higher than that found in cases of pancreatic carcinoma with distant metastasis（23.1%）, with a significant difference（P〈 0.05）. The expression rate of VEGF was 23.0% in pancreatic carcinoma of stage Ⅰ and Ⅱ and 32.1% in pancreatic carcinoma without distant metastasis, both lower than that of stage Ⅲ and Ⅳ （66.7%） and pancreatic carcinoma with distant metastasis （61.5%）. The difference was significant （P〈0.05）. The expression of TFPI-2 and VEGF was negatively correlated （r=-0.54, P〈0.05）. MVD was correlated with TFPI-2 expression. The value of MVD in the group with TFPI-2 expression （33.33±3.23） was lower than that in the group without TFPI-2 expression（36.00±＋3.17, P〈0.05）. Conclusion： TFPI-2 may inhib- it the angiogenesis of pancreatic carcinoma by reducing the expression of VEGF. Understanding its role can help prevent invasion and metastasis of pancreatie carcinoma.

关 键 词：胰腺肿瘤 新生血管化 组织因子途径抑制物2 

分 类 号：R735.9[医药卫生—肿瘤]