纤维支气管镜ThinPrep刷片细胞病理诊断在肺癌分型中的应用  

Value of ThinPrep Bronchial Brushing Cytology in the Typing and Diagnosis of Lung Cancer

作　　者：杨艳[1] 潘秦镜[1] 李中林[1] 赵琳琳[1] 曹箭[1] 

机构地区：[1]中国医学科学院中国协和医科大学肿瘤医院病理细胞室,北京市100021

出　　处：《中国肿瘤临床》2007年第23期1358-1361,共4页Chinese Journal of Clinical Oncology

摘　　要：目的:探讨纤维支气管镜ThinPrep刷片细胞病理在肺癌分型诊断中的价值。方法:选取我院纤支镜刷检细胞学诊断1365例,随诊所有患者的临床及病理资料。结果:其中有临床和/或病理诊断者969例。细胞学诊断肺恶性肿瘤的敏感性82.7%,特异性96.2%。分型诊断符合率鳞癌94.8%,腺癌92.3%,小细胞癌97.4%。细胞学分类诊断错误的23例中,分化差的癌22例占95.7%;细胞学未分类癌258例中分化差的癌153例占59.3%。结论:纤维支气管镜ThinPrep刷片细胞病理在肺癌诊断中具有较高的敏感性、特异性以及分型诊断符合率,但分化差癌是分型诊断的一个难点。Objective： To explore the value of ThinPrep bronchial brushing cytology in the subclassification of lung cancer. Methods： Data from a total of 1365 patients who underwent ThinPrep bronchial brushing cytology examination were collected and the related clinical and pathological data were analyzed. Results： There were 969 patients with clinical or/and pathological diagnosis. The sensitivity and specificity of ThinPrep bronchial brushing cytology were 82.7% and 96.2%, respectively. The accordant rate of cytology in subclassifieation was 94.8% in squamous cell carcinoma, 92.3% in adenocarcinoma and 97.4% in small cell lung cancer. In the 23 iucorrectly subclassified cases, 22 （95.7%） were poorly differentiated carcinomas, and in the 258 non-subclassified cases 153 （59.3%） were poorly differentiated carcinomas. Conclusion： ThinPrep bronchial brushing cytology has good sensitivity and specificity in the typing and diagnosis of lung cancer, but its value in the diagnosis of poorly differentiated carcinomas is limited.

关 键 词：纤维支气管镜刷片 THINPREP 细胞病理 肺癌 分型 

分 类 号：R734.2[医药卫生—肿瘤]