L-精氨酸、牛磺酸对大鼠血管损伤后血管平滑肌细胞增生的影响  

Effects of L -arginine and taurine on VSMC proliferation after the vascular injury of rat

作　　者：刘乃奎[1] 李楚文[1] 赵东[1] 常英姿[1] 唐朝枢[1] 苏静怡[1] 任晓燕[2] 

机构地区：[1]北京医科大学心血管基础研究所,北京100083 [2]青岛医学院病生教研室

出　　处：《中国病理生理杂志》1997年第3期286-290,共5页Chinese Journal of Pathophysiology

摘　　要：在大鼠血管内皮剥脱模型上,观察了L-精氨酸、牛磺酸及L-精氨酸+牛磺酸对血管损伤诱导的血管平滑肌细胞(VSMC)增生的影响。结果发现,内皮剥脱可致VSMC增生、内膜增厚;应用L-精氨酸、牛磺酸及L-精氨酸+牛磺酸治疗后,剥脱组VSMC增生明显受抑制,且L-精氨酸+牛磺酸对VSMC的抑制效应强于单纯应用L-精氨酸或牛磺酸组;L-精氨酸及L-精氨酸+牛磺酸治疗后,血管对乙酰胆碱(Ach)的内皮依赖性舒张,血管cGMP含量明显升高,然而L-精氨酸+牛磺酸组血管对Ach的内皮依赖性舒张性反应和cGMP含量的增加与单纯L-精氨酸组的差异无显著,这些结果说明 L-精氨酸和牛磺酸可能是通过增加NO含量和调整钙稳态等不同机制抑制VSMC增生。Effects of L -arginine, taurine and L-arginine + taurine on injury - induced VSMC (vascular smooth muscle cells) proliferation were investigated in the rat vessel de - endothelium model. The results showed that de - endothelium induced VSMC proliferation, intimal thichening; VSMC proliferation was significantly inhibited by L-arginine, taurine and L -arginine + taurine. However, inhibitory effect of L - arginine + taurine was stronger than L -arginine or taurine alone. L -arginine and L-arginine + taurine increased endothelium-dependent relaxation of vessels to acetylcholine and cGMP content in the denuded group, but increased endothelium - dependent relaxation and cGMP content in the L-arginine + taurine group was significantly different with L-arginine group. These findings indicated that L-arginine and taurine may inhibit VSMC proliferation by the different mechanisms of increased NO content and regulated calcium homeostasis etc.

关 键 词：精氨酸 牛磺酸 血管损伤 血管平滑肌 细胞增生 

分 类 号：R977.4[医药卫生—药品] R543[医药卫生—药学]