皮下脂膜炎样T细胞淋巴瘤的EB病毒感染和P53蛋白表达的关系  

The Significance of Epstein-Barr Virus Infection and Expression of P53 Protein in Subcutaneous Panniculitis-like T-cell Lymphoma

作　　者：万川[1,2] 王琳[1] 徐晨[1] 李俸媛[3] 刘卫平[3] 李甘地[3] 

机构地区：[1]四川大学华西医院皮肤性病科,四川成都610041 [2]江西省皮肤病专科医院,江西南昌330001 [3]四川大学华西医院病理科,四川成都610041

出　　处：《中国皮肤性病学杂志》2007年第12期714-716,共3页The Chinese Journal of Dermatovenereology

基　　金：2005年四川大学华西医院留学回国人员科研启动基金(编号136050122)

摘　　要：目的探讨皮下脂膜炎样T细胞淋巴瘤(SPTL)中EB病毒(EBV)的潜伏感染情况及其与P53蛋白表达的关系。方法采用EBER1/2原位杂交检测20例SPTL组织中的EBV感染;用免疫组化LSAB法检测P53蛋白表达。结果20例SPTL中5例(25%)EBER1/2原位杂交阳性,6例(30%)的P53阳性。统计学分析,二者具有相关性(r= 0.533,P<0.05)。结论部分SPTL病例伴EBV潜伏感染,伴有EBV感染的SPTL患者可能预后较差。SPTL组织中P53蛋白表达可能与EBV的感染有关。Objective To investigate the Epstein-Barr virus （EBV） latent infection and its correlation with expression of P53 protein in the subcutaneous panniculitis-like T-cell lymphoma （SPTL）. Methods Twenty cases of SPTL were analyzed, In situ hybridization for EBER1/2 and immunohistochemical staining for P53 were employed in this study, Results In the 20 cases of SPTL,the positive rate of EBER1/2 was 25% （5/20） and that of the P53 protein expression was 30% （6/20）, The two rates showed correlated statistically （ r = 0. 533, P 〈 0, 05 ）. Conclusion Some of SPTL are accompanied with EBV latent infection, which may signify a poor prognosis in these cases. The expression of P53 protein in SPTL may be related to the EBV infection,

关 键 词：淋巴瘤 T细胞 皮肤肿瘤 脂膜炎 EPSTEIN-BARR病毒 P53 

分 类 号：R739.5[医药卫生—肿瘤]