结直肠癌组织中肿瘤出芽与恶性程度分析  

Analysis between the malignant degree and tumor budding in colorectal carcinoma

作　　者：黄文斌[1] 赵建华[1] 黄悦[1] 李莉[1] 杨小兵[1] 王劲松[1] 张琦[1] 

机构地区：[1]南京医科大学附属南京第一医院病理科,江苏南京210006

出　　处：《南京医科大学学报（自然科学版）》2007年第12期1422-1424,1429,F0003,共5页Journal of Nanjing Medical University(Natural Sciences)

基　　金：江苏省卫生厅科研基金面上项目(H200744)

摘　　要：目的:探讨结直肠癌组织中肿瘤出芽的临床病理意义。方法:应用光镜和免疫组化EnVision法观察83例结直肠癌组织中肿瘤出芽的情况。结果:83例结直肠癌中有46例肿瘤发生了出芽(55.4%)。肿瘤出芽的发生率在有淋巴结转移者明显高于无淋巴结转移者(P<0.01);有淋巴管侵犯者肿瘤出芽的发生率明显高于无淋巴管侵犯者(P<0.01),pTNM分期中,Ⅲ期结直肠癌中肿瘤出芽的检出率明显高于Ⅱ期(P<0.01)。肿瘤出芽与患者年龄、性别、肿瘤部位、大小、分化程度和血管侵犯均无关(P>0.05)。结论:肿瘤出芽是提示侵袭性或浸润性生长的组织学特征,应用CKpan进行免疫标记可提高肿瘤出芽的检出率。Objective：To study the clinical pathologic significance of tumor budding in colorectal carcinoma. Methods：The tumor budding of 83 cases of colorectal carcinoma were detected by HE staining and EnVision immunohistochemical staining. Results： Tumor budding was found in 46 cases of colorectal carcinoma （55.4%）. Tumor budding was more frequently observed in colorectal carcinoma with lymph node metastasis than in those without lymph node metastasis （P 〈 0.01 ）. The incident of tumor budding was higher in colorectal carcinoma with lymphatic involvement than in those without lymphatic involvement （P 〈 0.01）. Among pTNM staging,the detection rate of tumor budding in colorectal carcinoma with Ⅲ stage was higher than those with Ⅱ stage （P 〈 0.01）. Tumor budding were not associated with sex, age, tumor size, site, differentiation and venous invasion （P 〉 0.05 ）. Conclusion： Tumor budding was a potential pathological marker suggesting aggressive or invasive growth of colorectal carcinoma. The detection rates of tumor budding was improved by CKpan immunohistochemistry.

关 键 词：结直肠癌 肿瘤出芽 免疫组织化学 病理学 

分 类 号：R735.37[医药卫生—肿瘤]