应用GTR膜与人工骨、bFGF等生物材料治疗牙周骨缺损的实验研究  

Use the biomaterials of GTR membrane,artificial bone and bFGF to treat periodontal bone damage:Experimental study

作　　者：曲晓娟[1] 朱建华[2] 张卫民[1] 张静莹[1] 童娟[1] 

机构地区：[1]大连大学医学院口腔医学系,辽宁大连116622 [2]佳木斯大学口腔医学院,黑龙江佳木斯154002

出　　处：《黑龙江医药科学》2007年第6期5-6,共2页Heilongjiang Medicine and Pharmacy

基　　金：大连市科技计划项目内容;项目编号:2004B3SF152

摘　　要：目的:本研究旨在通过动物实验证实GTR可促进牙周骨缺损的修复及增加新骨的形成,将GTR和人工骨,生长因子等生物材料联合使用可获得更多牙周新组织。方法:采用16只大耳白兔为实验对象,刮取兔牙骨质,去骨高度为牙骨质釉质界(CEJ)下6mm制成缺损,一侧用加入bFGF的人工骨和GTR膜包绕缺损,另一侧作为对照,通过光镜下观察载体材料吸收情况,结缔组织内炎症情况,结合上皮根向移行情况。结果:对照侧均呈现牙槽骨不愈合现象,实验侧有不同程度的牙槽骨骨愈合现象。结论:GTR膜与人工骨、bFGF等生物材料膜技术的应用有利于骨缺损的愈合。Objective：To approve that GTR can promote the repairing of the damage to the periodontal bones and the formation of the new bones and that the combined use of the biomaterials（such as GTR and artificial bones）and growth factors can produce more new periodontal tissues through animal experiments. Methods：Sixteen rabbits with big ears were used as the experimental objects which were removed of the cementum of the alveolar bone with the height of 6ram under the cement--enamel junction （CEJ） to produce the damage. We used the artificial bone with bFGF added and GTR membrane to have the damage wrapped on one side and the other side as the contrast, and observed the absorption of the carrier materials ,the inflammation of the inner connective tissues and the status of the junctional epithelium under the microscope. Results：The contrast side showed no concrescence of the alveolar bone cementum, and the experimental side showed the some degree of concrescence of the alveolar bone cementum. Conclusion ：The biomaterials such as GTR membrane, artificial bone and bFGF can promote the concrescence of the damaged bone.

关 键 词：引导组织再生术 人工骨 生长因子 

分 类 号：R782.13[医药卫生—口腔医学]