磁控溅射制备HA/Ti_6Al_4V复合材料种植体体外生物活性研究  

In Vitro Bioactivity of HA/Ti_6Al_4V Composite Implant Fabricated by RF Magnetron Sputtering

作　　者：张芹[1] 赵玉涛[2] 林东洋 

机构地区：[1]镇江市第一人民医院眼科,镇江212002 [2]江苏大学材料科学与工程学院,镇江212013

出　　处：《生物医学工程学杂志》2007年第6期1319-1324,共6页Journal of Biomedical Engineering

基　　金：江苏省自然科学基金资助项目(BK2003051)

摘　　要：研究了射频磁控溅射法制备的HA/Ti6Al4V复合材料种植体在模拟体液(Simulated body fluid,SBF)环境下的生物活性。利用扫描电镜(SEM)、能谱分析(EDS)、红外光谱(FTIR)及X-射线衍射(XRD)分析了该种植体涂层在模拟体液中浸泡前后的表面形貌、界面结合状态、晶体结构和相组成的变化,结果表明:该种植体涂层在模拟体液中存在溶解和新生物质在其表面沉积相伴的过程。其中,HA涂层表面的新生物质是一种缺钙型且含有CO32-的类骨磷灰石,其n(Ca)/n(P)比值约为1.56,晶粒小,结晶度低,接近于非晶态,这与自然骨中无机相的结构成分相似,因此具有良好生物相容性和生物活性。This is a report on the research of HA/Ti6Al4V composite implants that were successfully fabricated by radio frequency magnetron sputtering （RF-MS） technique. The mechanism and bioactivity of these implants immersed in simulated body fluid （SBF） were investigated. Changes in surface morphology, interracial bond state, crystal structure and phase composition of HA coating before and after immersing in SBF were characterized by Scanning electron microscopy （SEM）, Fourier transform infrared spectroscopy （FTIR）, energy dispersive spectroscopy （EDS） and X-ray diffraction （XRD）, Results indicate that a new substance on the surface of HA implant coatings produces accompanying with the dissolution of coatings. The substance is bone-like apatite containing CO3^2- and lacking of Ca^2＋. Its ratio of n（Ca）/n（P） is about 1.56, This substance has very small grain size and similarly amorphous structure. Its structure and composition are similar to those of natural bone. Thus, it has good biocompatibility and bioactivity.

关 键 词：HA/Ti6Al4V复合材料 种植体 模拟体液 生物活性 磁控溅射 

分 类 号：R318.08[医药卫生—生物医学工程]