国产盐酸环喷托酯滴眼液和托吡卡胺对眼睫状肌麻痹效果的比较研究  

A comparative study on the effects of cycloplegia between cyclopentolate hydrochloride and tropicamide

作　　者：刘念[1] 陈少芳[2] 李赛群[1] 聂昊辉[1] 钟兴武[1] 

机构地区：[1]中山大学中山眼科中心眼科学国家重点实验室,中国广东省广州市510060 [2]儿童医院眼科,中国广东省广州市510120

出　　处：《国际眼科杂志》2007年第6期1595-1597,共3页International Eye Science

基　　金：中国国家自然科学基金资助项目(No.30572007);中国教育部新世纪优秀人才支持计划(No.NCET-04-0812);霍英东青年教师基金(No.91043)~~

摘　　要：目的:观察国产盐酸环喷托酯滴眼液对人眼睫状肌麻痹和瞳孔散大的效果。方法:入选者48例左右眼随机分入试验组和对照组,分别滴用10g/L盐酸环喷托酯滴眼液和托吡卡胺滴眼液,每次1滴,隔5min再滴1次。于给药前1/6,给药后1/3,3/4,5/4,24,48h检查瞳孔直径和残余调节量。结果:国产盐酸环喷托酯的散瞳效应较托吡卡胺弱(P<0.01),但持续时间较长(P<0.01);盐酸环喷托酯的麻痹睫状肌效应较托吡卡胺强(P<0.01),持续时间也较长(P<0.01)。结论:盐酸环喷托酯滴眼液是一种安全有效的睫状肌麻痹剂,其麻痹睫状肌的效果优于托吡卡胺。AIM： To determine the effect of 10g/L cyclopentolate hydrochloride on cycloplegia and mydriasis. METHODS： Both eyes of 48 enrolled volunteers were randomly administered topically with either 10g/L cyclopentolate hydrochloride or tropicamide （2 times at 5 minutes interval）. Pupil size and residual accommodation were measured at 10 minutes before and 20 minutes, 45 minutes, 75 minutes, 24 hours, 48 hours after medicine was administered. RESULTS： The effect of cyclopentolate hydrochloride on mydriasis was weaker but longer than that of tropicamide （P 〈 0. 01 ）; in contrast, the effect of cyclopentolate hydrochloride on cycloplegia was stronger and longer than that of tropicamide （P〈0,01）. CONCLUSION： Cyclopentolate hydrochloride works better than tropicamide on cycloplegia. It can be used as a cycloplegic during optometry because of its safety and efficiency.

关 键 词：盐酸环喷托酯 托吡卡胺 睫状肌麻痹 瞳孔散大 验光 

分 类 号：R778.2[医药卫生—眼科]