保存角膜与新鲜角膜行大植片穿透角膜移植的临床研究  

Clinical study of penetrating keratoplasty with preserved or fresh large corneal graft

作　　者：胡竹林[1] 赵旭丽[1] 李妍[1] 

机构地区：[1]昆明医学院第四附属医院(云南省第二人民医院)眼科,中国云南省昆明市650021

出　　处：《国际眼科杂志》2007年第6期1634-1635,共2页International Eye Science

基　　金：中国云南省自然科学基金资助(No.2006C0077M);中国云南省教育厅基金资助(No.06Y085C)~~

摘　　要：目的:比较用保存和新鲜的角膜植片行大植片穿透性角膜移植术后的临床疗效和并发症。方法:回顾性分析2003-12/2006-12我院收治的角膜严重病变并须行大植片穿透角膜移植的患者108例(116眼),其中用保存角膜植片移植治疗63眼,用新鲜角膜植片移植治疗53眼。比较两组术后的视力改变、角膜植片及并发症情况。结果:保存角膜植片移植组的视力提高44眼(69.8%),稳定10眼(15.9%),下降9眼(14.3%),植片排斥反应8眼(12.7%);新鲜角膜移植组的视力提高24眼(45.3%),稳定17眼(32.1%),下降12眼(22.6%),植片排斥反应15眼(28.3%)。两组术后的视力和植片排斥反应率均有显著差异(P<0.05)。结论:大植片穿透性角膜移植时,保存的植片较新鲜植片能降低移植术后的免疫排斥发生率,延长植片的存活时间。AIM： To evaluate the clinical effects and complications of penetrating keratoplasty with preserved or fresh large corneal graft. METHODS： A follow-up was carried out on patients who received penetrating keratoplasty with preserved or fresh large corneal grafts between December 2003 and December 2006. A total of 108 cases （116 eyes） were involved in the study. Sixty-three eyes were treated with preserved large corneal grafts; 53 eyes were treated with fresh large corneal grafts. The vision, the incidence of graft immune rejections and complications after operations were compared. RESULTS： The vision condition of the preserved corneal graft group was as follows： 44 eyes（69.8%）were improved, 10 eyes （15. 9%） were sustained, 9 eyes （14.3%） descended. The vision condition of the fresh corneal graft group was as follows： 24 eyes （45.3%）were improved, 17 eyes （32.1%）were sustained, 12 eyes （22. 6%） descended. And the incidence of graft immune rejection was respectively 8 eyes （12.7%） and 15 eyes （28.3%） in these two groups. There were significant statistical differences between these two groups in respect of vision and immune rejections. （ P 〈 0.05） . CONCLUSION： Preserved corneas may reduce the incidence of graft immune rejections and prolong the corneas＇ survival time, especially in those who must be treated with large grafts.

关 键 词：大植片 角膜移植术 穿透性 

分 类 号：R779.65[医药卫生—眼科]