非血缘外周血干细胞移植后cGVHD中枢神经系统受累  

Involvement of Central Nervous System Caused by Chronic Graft-versus-host Disease after Allogeneic Hematopoietic Stem Cell Transplantation

作　　者：刘芳[1] 夏凌辉[1] 方峻[1] 宋善俊[1] 洪梅[1] 

机构地区：[1]华中科技大学同济医学院协和医院血液病研究所,武汉430022

出　　处：《放射学实践》2007年第12期1279-1281,共3页Radiologic Practice

摘　　要：目的:提高对外周血干细胞移植后发生以中枢神经系统受累为主要表现的慢性移植物抗宿主病(cGVHD)的认识,早期诊断、及时治疗。方法:报告一例非血缘外周血干细胞移植术(MUD-PBSCT)后发生以中枢神经系统受累为主要表现的慢性移植物抗宿主病病例及诊治经过,并对相关文献进行复习。结果:患者于移植后9个月出现发热和皮疹,伴渐进性智力障碍、口齿不清、认知力下降、肾病综合征等临床表现,头颅MRI显示给予MMF2g/d、FK5062.5mg/d及甲强龙治疗后,病情明显改善。结论:非血缘异基因造血干细胞移植MUD-PBSCT后,慢性GVHD以中枢神经系统受累为主要表现者国内少有报道,及时诊断并给予有效治疗十分重要。Objective： To raise the understanding of the damage of central nervous system caused by chronic graft-versus-host disease （GVICID） for an early diagnosis and prompt treatment. Methods： A case with impairment of central nervous system caused by chronic GVHD after matched unrelated donor peripheral blood stem cell transplantation （MUD-PBSCT） was reported and related a literature was reviewed. Results： A patient with acute lymphocytic leukemia was treated by MUD- PBSCT. Nine months later, the patient had fever and extensive skin rash accompanied with gradual intelligence obstruction, unclear enunciation, decreased cognition and nephropathy syndrome. The patient＇s condition was improved significantly after being treated with mycophenolate mofetil （MMF）, taerolimus and methylprednisolone. Conclusions： Chronic GVHD is a common complication after MUD-PBSCT,early diagnosis and treatment are very important. imaging

关 键 词：外周血干细胞移植 移植物抗宿主病 磁共振成像 

分 类 号：R733.7[医药卫生—肿瘤]