胃癌中微血管密度与临床病理因素和预后的关系  

Relationship among Intratumor Microvessel Density,Clinicopathological Features and Prognosis in Gastric Carcinoma

作　　者：刘俊[1] 陈莉[1] 钱铮[2] 

机构地区：[1]南通大学医学院病理教研室,226001 [2]江苏省海门市人民医院病理科

出　　处：《天津医药》2007年第12期915-917,F0003,共4页Tianjin Medical Journal

摘　　要：目的:观察胃癌中CD34表达的微血管密度(MVD)与胃癌临床病理因素和预后的相关性。方法:应用免疫组化SP法分别检测86例胃癌组织中CD34的基因表达,结合临床病理因素和随访资料分析MVD对胃癌预后的影响。结果:胃癌中MVD值均为(27.8±10.3)/HP,正常胃黏膜中MVD值为(13.02±8.25)/HP,前者高于后者(t=4.371,P<0.01)。MVD与癌浸润程度、淋巴结转移、肿瘤临床分期呈正相关(均P<0.05),与患者生存率呈负相关(P<0.05),其中MVD>15/HP的5年生存率低于MVD≤15/HP组(P<0.05)。结论:胃癌中MVD与癌生物学行为密切相关,其增加能显著上调和促进癌进展,是判断预后的重要指标。Objective： To study the expression of CD34 of microvessel density （MVD） and the relationship among MVD, clinicopathological features and prognosis in patients with gastric carcinoma. Methods： Expression of CD34 in 86 cases of gastric carcinoma and l0 cases of normal gastric mucosa were detected by immunohistochemical SP method. The effect of MVD was assessed by comparing with clinicopathological features and follow-up data of 86 patients. Results： The positive rate of CD34 expressed MVD〉IS/HP in 86 cases of gastric carcinoma was 62.79%. The values of MVD were higher in gastric carcinoma than those in normal mucosa （t =4.371 ,P 〈 0.01 ）and were positively related to infiltration depth, lymph node metastasis and the clinical stages（P 〈 0.05, respoctively）.The values of MVD were negatively related to the survival stage（P〈0.05）. The 5 years survival rate was significantly lower in group of MVD〉IS/HP than that of MVD≤15/HP （P 〈 0.05）. Conclusion： The value of MVD in gastric carcinoma is closely correlated with its biological behavior, which significantly up-regnlatod developing of gastric carcinoma. The value of MVD is a significant indicator for estimating prognosis.

关 键 词：胃肿瘤 癌 毛细血管 抗原 CD34 预后 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]