VEGF、TSP-1与内分泌肿瘤血管生成的研究进展  

Study Progress of VEGF and TSP-1 with Angiogenesis of Endocrine Tumors

作　　者：覃丹露[1] 罗佐杰[1] 

机构地区：[1]广西医科大学第一附属医院内分泌科,南宁530021

出　　处：《医学综述》2007年第19期1446-1448,共3页Medical Recapitulate

基　　金：广西科技厅自然科学基金(桂科自0542085);广西教育厅科研项目(桂教科研[2004]20号)

摘　　要：血管内皮生长因子是重要的血管生成因子,可调节内皮增殖、血管生成、调节血管通透性及血栓形成。血小板反应蛋白1为一抗血管生成因子,参与细胞黏附、迁移、浸润、增殖、分化和血管生成等。目前,研究提示二者在内分泌肿瘤中的表达异常,参与内分泌肿瘤发生、发展,为内分泌肿瘤的诊断、治疗提供依据。VEGF is an important angiogenesis factor,which can regulate endothelial proliferation, angiogenesis, permeability of blood vessel, thrombogenesis. TSP- 1 is an anti- angiogenesis factor, which participates in cell adhesion, migration, infiltration, proliferation, differentiation, angiogenesis and so on. Recent study manifested that abnormal expression of this two factors in the endocrine tumors participates in tumorigenesis and development of endocrine tumors, which offer an evidence for diagnosis and therapy of endocrine tumors.

关 键 词：内分泌腺肿瘤 血管内皮生长因子 血小板反应素 新生血管化 

分 类 号：R736[医药卫生—肿瘤]