凋亡抑制蛋白survivin与胰腺癌  

Apoptotic inhibitory Protein Survivin and Pancreatic Cancer

作　　者：梁丹红[1] 张厚德[1] 

机构地区：[1]广东医学院附属深圳市第六人民医院消化内科,广东深圳518052

出　　处：《医学综述》2007年第19期1463-1465,共3页Medical Recapitulate

摘　　要：Survivin是新近发现的一种凋亡抑制蛋白,由142个氨基酸组成,氨基端含有一个保守的Cys/HisBIR功能区,主要通过抑制caspase-3和caspase-7的活性而发挥抗凋亡作用,survivin选择性地表达于肿瘤组织而在正常成熟组织中几乎不表达。近年来,已有很多学者开始研究survivin与肿瘤关系,但在胰腺癌方面的研究甚少,阐述survivin在胰腺癌中的表达,为胰腺癌的诊断和治疗提供了新的方向。Survivin is a recently discovered apoptotic inhibitory protein, which is composed of 142 amino acids. There is a functional domain having conservative Cys/His single Baculovirus IAP Repeat （BIR） in Nterminal, which can play its effect of anti-apoptosis by inhibiting the activity of caspase-3 and caspase-7. Survivin has selective expression in tumor tissue and scarely expression in normal tissue. Although much of the current research in this field is focused on human cancer, the area about cancer of pancreas is very few. The purpose of this article is to explain survivin expexpression in pancreatic cancer in order to provide new direction for diagnosis and therapy of this cancer.

关 键 词：胰腺肿瘤 SURVIVIN 凋亡抑制 治疗 

分 类 号：R735.9[医药卫生—肿瘤]