载两性霉素B的PLA-PEG纳米粒在小鼠体内的分布  

Distribution of Amphotericin B Loaded Polylactic Acid-polyethylene Glycol Nanoparticles in Mice

作　　者：徐楠[1] 郁晓[2] 范国荣[3] 温海[1] 陈江汉[1] 

机构地区：[1]第二军医大学长征医院皮肤科,上海200003 [2]上海同济大学材料科学与工程学院,上海200092 [3]第二军医大学药学院药物分析教研室,上海200433

出　　处：《中国医药工业杂志》2007年第12期849-851,共3页Chinese Journal of Pharmaceuticals

基　　金：上海市科委纳米专项基金(0452nm016)

摘　　要：采用改良的相分离法制备载有两性霉素B(1)的聚乳酸-聚乙二醇纳米粒,HPLC法检测小鼠脑组织及其它脏器中的药物浓度。以1粉针剂和1脂质体为对照,评价纳米粒的脑靶向作用。在小鼠脑内1粉针剂组未能检测出药物,1脂质体组于3h后能测得微量药物,1纳米粒组小鼠给药30min后脑内浓度达33.5ng/g,12h达最高(160.4ng/g)。The polylactic acid-polyethylene glycol nanoparticles loaded with amphotericin B （1） were prepared by modified phase separation method. The drug concentrations in plasma, brain and several organs of mice were determined by HPLC. The brain-targeting effect of the prepared preparation was investigated using 1 injection and 1 liposomes as the control groups. The results showed that in brain the drug could not be detected in the injection group and trace amount drug was detected after administration for 3h in the liopsomes group. While in nanoparticles group, the drug concentration in brain was 33.5ng/g at 30min and the maximum concentration detected was 160.4ng/g at 12h.

关 键 词：两性霉素B 聚乳酸-聚乙二醇共聚物 纳米粒 脑靶向 

分 类 号：R944.9[医药卫生—药剂学]