固本消瘤胶囊联合FOLFOX4方案治疗晚期大肠癌的临床研究  

Clinical Study of Guben Xiaoliu Capsule Combined with FOLFOX4 Regimen in Treating Advanced Colorect Cancer

作　　者：胡凤山[1] 张青[1] 王笑民[1] 杨国旺[1] 赵文硕[1] 

机构地区：[1]首都医科大学附属北京中医医院肿瘤科,北京100010

出　　处：《中国中医药信息杂志》2007年第7期13-14,共2页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：北京中医科技资助项目(JJ-2005-27)

摘　　要：目的观察固本消瘤胶囊联合FOLFOX4方案治疗晚期大肠癌的疗效。方法78例晚期大肠癌患者随机分成治疗组(38例)、对照组(40例)。78例晚期大肠癌患者接受OXA85mg/m2静脉点滴2h,d1;CF200mg/m2静脉点滴2h,5-FU400mg/m2静脉推注后续以600mg/m2持续静脉点滴22h,d1-2;2周重复,为1周期。治疗组同时口服固本消瘤胶囊。应用4周期后判定疗效。结果治疗组与对照组的临床受益率(CR+PR+SD)分别为76.3%、57.5%(P<0.05)。固本消瘤胶囊联合FOLFOX4方案能提高患者的细胞免疫功能,缓解化疗药物的毒副反应,改善患者的生活质量。结论固本消瘤胶囊联合FOLFOX4方案治疗晚期大肠癌有较好的近期疗效。Objective To observe effect of Guben Xiaoliu capsule combined with FOLFOX4 regimen in treating advanced colorect cancer patients. Methods 78 advanced colorect cancer patients were randomly assigned to treatment group （38 patients） and control group （40 patients）. Oxaliplatin 85 mg/m^2 iv infusion for 2 hours, dl. CF 200 mg/m^2 iv infusion for 2 hours followed by 5-FU 400 mg/m^2 iv infusion for 22 hours, d1-2. Every two weeks was a cycle. The control group was treated by FOLFOX4 regimen, while Guben Xiaoliu capsule was added in the treatment group. Patients were evaluated after 4 cycles. Clinical beneficial rate （CR＋PR＋SD） of treatment and contral group were 76.3% and 57.5% respectively （P〈0.05）. Guben Xiaoliu capsule decreased blood hypercoagulability, improved cellular immune function of patients, relieved myelosuppression of chemotherapeutic agents and improved quality of life of patients. Conciusion FOLFOX4 regimen combined with Guben Xiaoliu capsule had better effect in the treatment of advance colorect cancer patients.

关 键 词：固本消瘤胶囊 FOLFOX4方案 晚期大肠癌 

分 类 号：R735.34[医药卫生—肿瘤]