妇科肿瘤患者尿中多胺值测定  

Urinary Polyamines in Patients with Gynecologic Neoplasms

作　　者：令狐华[1] 徐小蓉[1] 

机构地区：[1]重庆医科大学附属第一医院,重庆630042

出　　处：《浙江肿瘤》1997年第3期137-138,共2页

摘　　要：目的：阐明多胺对妇科肿瘤的诊断及治疗效果判断的意义。方法：本文用固相萃取及高效波相色谱测定法检测并比较了34例妇科恶性肿瘤（恶性组）、35例良性肿瘤患者（良性组）及37例健康女性问4照组）的尿多胺值，且短期随访了16例卵巢恶性肿瘤患者治疗（根治性手术或细胞灭减术及一次化疗）前、后尿中多胺值的变化。结果：恶性组（含复发癌4例）多胺值显著高于良性组及对照组;同样，卵巢恶性肿瘤患者的测定值亦显著高于卵巢良性病变及健康对照。16例卵巢恶性肿瘤患者经有效治疗后尿多胺值明显降低。结论：提示多胺不能作为某一特定肿瘤的特异性诊断标准，但对判断肿瘤的良、恶性以及治疗疗效和预测恶性肿瘤复发有一定意义。Purpose: To evaluate the role of polyamines in the diagnosis and therapeutic effectiveness in gynecologic neoplasms.Method: Urinary polyamines from 69 patients with gynecologic tumors were analysed by solid phase extraction, highperformance liquid chromatography. Rcsults: The respective value of total polyamines, putrecine, spermidine and spermine from urine of 34 patients with malignant diseases were significantly higher than those with benign neoplasms (n= 35) and healthy controls (n= 37). In similarity, the results of patients with ovarian cancer (n=24) were also higher than those with 23 benign ovarian neoplasms and healthy controls (n=37) significantly. After radical opeIation in combinatlon with efficient chemotherapy, the value of urinary polyamines in 16 ovarian cancer patients was much lower compared with their Preopcrative level. Conclusions: Urinary polyamines may not be consldered as a specific diagnostic indication but seems to be a malignant index for gynecologic neoplasms, and the change of their level can be used to judge the effectiveness of treatment.

关 键 词：尿多胺 妇科肿瘤 卵巢肿瘤 测定 

分 类 号：R737.3[医药卫生—肿瘤]