46例颅内恶性肿瘤多途径联合化疗分析  

An Analysis of Combined Chemotherapy in 46 Patients with Intracranial Malignant Tumors

作　　者：孙印臣[1] 赵会锋[1] 谭振美[1] 李铁林[1] 段传志[2] 

机构地区：[1]张家口解放军第251医院,张家口075000 [2]广州珠江医院,广州510282

出　　处：《浙江肿瘤》1997年第1期12-13,共2页

摘　　要：目的：为了探讨改进传统化疗方法（静脉、颈总动脉给药）治疗颅内恶性肿瘤存在较严重并发症从而影响治疗效果的缺点。方法：采用多途径（经微导管超选择供瘤动脉、静脉、口服等）联合化疗方法，共治疗了46例不同性质的颅内恶性肿瘤。使用两种用药配伍；一种是阿霉素、丝裂霉素、卡氮芥和司莫司汀，治疗16例；另一种是VM26和司莫司汀，治疗30例。结果：该方法克服了传统化疗方法所存在的缺点，总有效率为80.40％。结论：此方法用于治疗颅内恶性肿瘤，效果优于单纯手术、放疗和化疗。Purpose: To study and overcome the deficiency of severe complications after the intracranial malignant tumors beingtreated with conventional chemotherapy. Method: A total of 46 patients with different kinds of intracranial malignant tumors were treat-ed with multiple route combined chemotherapy (via tumor artery, vein and through oral administration) including: ①adriamycin, mito-mycin, BCNU and MeCCNU were combinedly administered to 16:② VM26 and MeCCNU were combinedly administered to 30. Results:The total response rate was 80. 40% and the therapeutic method overcame the deficiency of conventional chemotherapy. Conclusion: Webelieve that the method is better than the conventional chemotherapy, radiotherapy and operation in treating intracranial malignant tu-mors.

关 键 词：脑肿瘤 联合化疗 阿毒素 丝裂霉素 卡氮芥 

分 类 号：R739.410.5[医药卫生—肿瘤]