海带多糖对受辐射损伤雄性大鼠睾丸组织的保护作用  

Effect of laminaria japonica polysacclmrides （LJP） on radiation damage of testis tissue in male rats

作　　者：任世成[1] 罗琼[1] 杨明亮[1] 杨佳娟[1] 闫俊[1] 李卓能[1] 王丽红[1] 崔晓燕[1] 

机构地区：[1]武汉大学公共卫生学院营养与食品卫生学系,430071

出　　处：《中华放射医学与防护杂志》2007年第6期540-543,共4页Chinese Journal of Radiological Medicine and Protection

基　　金：湖北省科技厅重点攻关项目（2001AA307B）

摘　　要：目的探讨海带多糖（KIP）对辐射导致的大鼠睾丸组织损伤的影响。方法将Wistar大鼠40只，随机分为正常对照组、阳性对照组、阴性对照组和KIP实验组，灌胃10d后行一次性γ射线局部照射，照射剂量6．0Gy/只，72h后观察睾丸组织形态学改变，测定睾丸和附睾的脏器系数，计算精子数和精子活率，检测睾丸组织中超氧化物歧化酶（SOD）活性和丙二醛（MDA）含量。结果海带多糖可使受损的睾丸组织形态有不同程度修复；能增加睾丸和附睾的脏器系数；提高精子数量和活力；增强大鼠睾丸组织SOD活性，降低MDA含量。结论海带多糖对辐射造成的睾丸组织损伤具有明显的保护作用。Objective To observe the effect of laminaria japonica polysaccharides （LIP） on local radiation damage of testis tissue in male rats. Methods The Wistar rats were randomly divided into 4 groups ： the normal group, the model group, positive control group and LJP treatment group （50 mg·kg^-1 ·d^-1 ） . LJP was applied to the treatment group for 10 d before local irradiation with γ-ray （6.0 Gy） . The morphological change of the testis, organ index of testis and epididymides, sperm count, motility rate, superoxide dismutase （SOD） activity and malonic aldehyde （MDA） contents were measured. Results LJP could make the damaged testis recover to near normal, elevate the organ index of testis and epididymides, promote the sperm count and motility rate, increase the activity of SOD and decrease the contents of MDA in testis tissue. Conclusions LJP could inhibit testis tissue damage induced by local radiation, hence enhance the significant radioprotective effect to testis tissue. LJP has the conspicuous protective effect on radiation damage of testis tissue.

关 键 词：海带多糖 辐射 睾丸组织损伤 

分 类 号：R686[医药卫生—骨科学]