MR灌注成像在评估脑胶质瘤放疗效果中的应用  

Application of MR Perfusion - weighted Imaging to Evaluation of Radiotherapeutic Effect on Glomas

作　　者：刘鹏飞[1] 那婧[1] 王晓睿[1] 王媛[1] 戴险峰[1] 

机构地区：[1]哈尔滨医科大学附属第一医院磁共振室,黑龙江哈尔滨150001

出　　处：《中国临床神经外科杂志》2007年第12期712-715,共4页Chinese Journal of Clinical Neurosurgery

基　　金：黑龙江省科技攻关项目(编号GC03C606-3);黑龙江省教育厅科技项目(编号11511192)基金资助

摘　　要：目的探讨MR灌注成像在评估脑胶质瘤放疗疗效中的应用价值。方法对25例脑胶质瘤术后患者于放疗前及放疗后3、6个月行MR灌注成像及常规MRI检查。由灌注数据获取脑血容量(CBV)图和脑血流量(CBF)图,计算出病灶的最大相对局部脑血容量(rCBV)值和最大相对局部脑血流量(rCBF)值。结果25例脑胶质瘤术后放疗前肿瘤区的rCBV值和rCBF值分别为6.32±2.14和5.49±1.98,与正常脑组织的2.58±1.21和2.17±1.19相比,显著升高(P<0.01)。其中11例放疗后rCBV值和rCBF值与放疗前相比,显著下降(P<0.01),其中5例证实为放射性脑坏死;另14例放疗后rCBV值和rCBF值与放疗前相比,有不同程度升高,但无统计学意义(P>0.05)。其中7例证实为肿瘤伴部分放射性坏死组织,2例死亡,5例再次行放射治疗取得较好疗效。结论MR灌注成像可作为评估脑胶质瘤放疗疗效的一项重要指标,并有助于下一步治疗方案的制定。Objective To investigate the value of MR perfusion weighted imaging（PWI） to the evaluation of radiotherapeutic effect on gliomas. Methods MR PWI and conventional MRI examinations were performed respectively before radiotherapy and 3 and 6 months after radiotherapy in 25 patients with gliomas. The perfusion dada were deconvoluted to get color maps of cerebral blood volume （CBV） and cerebral blood flow （CBF）. The relative values of regional CBV （rCBV） and regional CBF （rCBF） of the gliomas and cerebral tissues opposite to the gliomas were computed. Results In the gliomas and the cerebral tissues opposite to the gliomas to the gliomas, the rCBV were 6.32±2.14 and 2.58±1.21 respectively, and rCBF were 5.49±1.98 and 2.17±1.19 respectively before the radiotheraphy. The rCBV and rCBF of the gliomas increased before the radiotherapy in 25 patients compared to the cerebral tissues opposite to the gliomas （P〈O.O1）. Three and six months after the radiotherapy, rCBV and rCBF significantly decreased in 11 patients （P〈0.01）, of whom, 5 had cerebral radionecrosis and 6 did not. The rCBV and rCBF of the gliomas increased to different extents after radiotherapy in 14 patients, of whom, 7 had the tumors with regional radionecrosis and 7 not. Conclusion MR PWI is a good method to evaluate the radiotherapeutic effect on the gliomas.

关 键 词：磁共振成像 灌注成像 脑胶质瘤 放疗 

分 类 号：R739.41[医药卫生—肿瘤] R445.2[医药卫生—临床医学]