烟雾病颞浅动脉、脑膜中动脉的组织病理学研究  

Histopathological study of superficial temporal arteries and middle meningeal arteries in Moyamoya disease

作　　者：金洪[1] 邹丽萍[1] 段炼[2] 周春菊[3] 齐翔[4] 陈春红[1] 王晓慧[1] 王旭[1] 

机构地区：[1]首都医科大学附属北京儿童医院神经内科与康复中心,100045 [2]中国人民解放军军事医学科学院附属医院神经外科 [3]首都医科大学附属北京儿童医院病理科,100045 [4]首都医科大学附属北京儿童医院神经外科,100045

出　　处：《临床神经病学杂志》2007年第6期404-406,共3页Journal of Clinical Neurology

基　　金：首都医学发展科研基金资助项目(2005-1012)

摘　　要：目的探讨烟雾病颞浅动脉和脑膜中动脉的组织病理学改变。方法对12例烟雾病患者(其中5例儿童)的颞浅动脉和脑膜中动脉分支活检标本进行组织病理学观察,并与2例非烟雾病患者的颞浅动脉分支对照。结果烟雾病患者颞浅动脉分支的内膜呈局灶性纤维细胞性增厚伴弹力膜增生分层,中膜平滑肌细胞变性,中膜层局部变薄;脑膜中动脉分支的形状明显不规则,管壁变薄,管腔扩张,部分中膜平滑肌细胞萎缩或空泡变,儿童与成人患者的病理改变相似。结论烟雾病颈内、颈外动脉系统的病理学改变相似,主要为血管内膜局灶性纤维细胞性增厚及中膜平滑肌细胞变性。Objective To explore the histopathological changes of the superficial temporal arteries（STAs） and middle meningeal arteries（ MMAs ） in Moyamoya disease （MMD）. Methods The histopathological changes were observed in the branches of STAs and MMAs from 12 patients （including 5 children） with MMD, in comparison with the branches of STAs taken from 2 patients with other diseases. Results Pediatric and adult patients with MMD showed similar histopathological changes in the arterial specimens. The STAs were generally characterized by focal fibrocellular intimal thickening with laminated proliferated elastica, degeneration of smooth muscle ceils （SMCs） in media and partial attenuation of media, while the MMAs were mainly featured by apparent malformation with attenuated wall and dilated lumen as well as the atrophic or vacuolated SMCs in partial media. Conclusions The pathological changes in the external carotial arteries and internal carotial arteries in MMD are similar. The main charactor are focal fibrocellular intimal thickening and degeneration of SMCs in media.

关 键 词：烟雾病 组织病理学 

分 类 号：R361.2[医药卫生—病理学] R743[医药卫生—基础医学]