中国人群载脂蛋白B基因XbaI多态性与脑梗死关系的Meta分析  

Meta-analysis on relationship between ApoB gene XbaI polymorphism and cerebral infarction in Chinese population

作　　者：张硕[1] 郭阳[2] 马燕[1] 

机构地区：[1]中国医科大学第二临床学院,沈阳110004 [2]中国医科大学附属盛京医院神经内科

出　　处：《临床神经病学杂志》2007年第6期423-425,共3页Journal of Clinical Neurology

摘　　要：目的对中国人载脂蛋白B基因XbaI酶切位点限制性片段长度多态性与脑梗死关系进行Me-ta分析。方法通过文献检索收集相关病例对照研究,对纳入文献进行异质性检验及合并分析。结果纳入11篇文献合并统计,总体效应检验未发现统计学上的差异(Z=1.72,P=0.08);分组分析发现北方人群XbaI多态性位点在X-X+/X+X+基因型水平与脑梗死发病有统计学意义(OR=2.66,95%CI:1.67～4.24);南方人群在此基因型水平无统计学差异(OR=1.26,95%CI:0.90～1.77)。结论Meta分析提示载脂蛋白B基因XbaI多态性位点可能增加中国北方人群脑梗死风险,对南方人群的影响尚不确定。Objective The relationship between XbaI polymorphism of ApoB gene and cerebral infarction（CI） among Chinese population was assessed by Meta-analysis. Methods All related case-control studies were collected from all publications, the relevant studies were identified after eliminating those poor-qualified studies. Meta-analysis was conducted for investigating heterogeneity among individual studies, and summarizing the effects across studies. Results The combined data statistics revealed the frequencies of the X^- X^＋/X^＋ X^＋ genotypes showed no statistically difference （ Z = 1.72,P = 0. 08）. Through the subgroup analysis, it was obviously increase the risk of CI in Chinese northern population（ OR=2. 66,95% CI：1. 67 ～ 4. 24）, but no statistically difference in Chinese southern population （OR = 1.26,95% CI：0. 90 ～ 1.77 ）. Conclusions ApoB gene XbaI polymorphism may be significantly associated with susceptibility of CI in Chinese northern population, but not a definite risk for Chinese southern population.

关 键 词：载脂蛋白B 脑梗死 多态性 META分析 

分 类 号：R743[医药卫生—神经病学与精神病学]