非小细胞肺癌红细胞膜带3蛋白功能的观察  

Observation of the function of erythrocyte membrane band3 protein of nonsmall cell lung cancer patients

作　　者：刘晓滨[1] 白淑芝[2] 姜晓姝[2] 马艳伟[1] 邢丽娜[1] 

机构地区：[1]哈尔滨医科大学第二临床医学院肿瘤放疗科 [2]哈尔滨医科大学病理生理学教研室,黑龙江哈尔滨150081

出　　处：《哈尔滨医科大学学报》2007年第6期535-536,540,共3页Journal of Harbin Medical University

基　　金：黑龙江省自然科学基金资助项目(D0048)

摘　　要：目的观察早晚期非小细胞肺癌患者红细胞膜带3蛋白功能变化。方法正常对照组:健康成年人15名;早期组:Ⅰ、Ⅱ期非小细胞肺癌15例;晚期组:Ⅳ期非小细胞肺癌15例。应用Cl-荧光探针6-甲基-3-磺丙基-1-喹啉-水化合物(SPQ)分别检测3组红细胞膜带3蛋白的阴离子转运活性。结果晚期组患者红细胞膜带3蛋白的离子转运活性明显比早期组升高。结论晚期非小细胞肺癌红细胞膜带3蛋白的离子转运活性升高。提示带3蛋白的阴离子转运活性与非小细胞肺癌的发生、发展有关。Objective To investigate the function of erythrocyte membrane band3 protein of non-small cell lung cancer patients at stage- Ⅰ , Ⅱ and Ⅳ. Methods Normal adults control, patients at stage- Ⅰ , Ⅱ and Ⅳ were 15 examples respectively. The transport activity of band3 protein was measured by using a chloride fluorescent probe SPQ. Results The results showed that band3 protein transport activity of patients at stage-Ⅳ was significantly higher than stage- Ⅰ and Ⅱ . Conclusion Band3 protein transport activity of non-small cell lung cancer patients at stage-Ⅳ increased significantly compared with stage- Ⅰ and Ⅱ . The results above indicated that band3 protein anion transport activity may play a crucial role during the genesis and growth of non-small cell lung cancer.

关 键 词：带3蛋白 阴离子转运活性 非小细胞肺癌 

分 类 号：R732.23[医药卫生—肿瘤]