大脑胶质瘤病诊断和治疗的探讨  

Study on diagnosis and treatment of gliomatosis cerebri

作　　者：王建设[1] 张涛[2] 李向阳[2] 唐天友[1] 章龙珍[1] 姚元虎[1] 

机构地区：[1]徐州医学院附属医院放疗科,江苏徐州221002 [2]徐州医学院第二附属医院放射科,放疗科江苏徐州221002

出　　处：《中国癌症杂志》2007年第12期955-959,共5页China Oncology

摘　　要：背景与目的:大脑胶质瘤病(gliomatosis cerebri,GC)是一种罕见的颅内肿瘤,定义为大脑肿瘤胶质细胞弥散性的浸润,临床诊断和治疗困难。本研究探讨GC的诊断和治疗方法。方法:回顾性分析2001年1月-2007年7月年在我科诊治的11例GC患者的临床表现、检查结果、治疗方法和预后情况,结合国内外文献分析讨论。结果:本病主要临床表现为进行性颅内压增高和癫痫反复发作,同时伴有不同程度的智力与精神障碍。病理检查多为低级别胶质瘤。影像学检查示病变弥散,侵犯大脑半球2个或2个以上脑叶。8例患者行肿瘤切除术,11例行术后放疗。随访至2007年7月有7例死亡,诊断后的中位生存期是22个月。结论:GC的诊断可参考临床表现与MRI检查,确诊需靠病理学检查;综合利用手术、化疗和放疗能有效的延长患者的生存期,提高生存质量。Background and purpose： Gliomatosis cerebri （GC） is a rare disease, defined as a diffuse neoplastic glial cell infiltration of the brain. Diagnosis and maoagenleut of GC are diffieuh, This study was done to discuss the diagnosis and treatment of GC. Methods： The clinical manifestations, lab test results, therapeutic methods were analyzed retrospectively in 11 cases with GC, which were diagnosed and treated in our hospital from January 2001 to July 2007. Results： The main clinical manifestations tff the 11 cases were progressive intracranial hypertension, repeated epileptic attack, accompanied by various degrees of mental retardation and dysphrenia. GC usually demonstrates histomorphnlogical features of a low-grade tumor. Radiological examination revealed diffuse lesions law,lying both grey and white matter, two or more regions, and invaded in both cerebral hemispheres. 8 cases underwent partial removal of the tumor and all patients underwent postoperative radiotherapy. 7 cases died in follow-up period. Median survival time after diagnosis was 22 ,Months. Conclusions： The clinical and MRI features were helpful in the diagnosis of cerebral glinmatosis, however, the confirmation should depend on pathological study. Combined therapy of surgery, radiotherapy and chemotherapy might prolong the stuwival time and improve the quality of life for the patients with GC.

关 键 词：大脑胶质瘤病 磁共振成像 诊断 放射治疗 化疗 

分 类 号：R739.41[医药卫生—肿瘤]