肿瘤转移抑制基因KAI1/CD82和雌孕激素受体在子宫内膜癌组织中的表达及其临床意义  

Expressions of Metastasis Suppressor Gene KAI1,Estrogen Receptor and Progesterone Receptor in Endometrial Carcinoma Tissues and Their Clinical Significance

作　　者：胡春霞[1] 翁丹卉[1] 蒋学锋[1] 朱涛[1] 李红雨[1] 金松[2] 何超蔓[2] 卢运萍[1] 王世宣[1] 马丁[1] 

机构地区：[1]华中科技大学同济医院肿瘤生物医学中心,武汉430030 [2]海南医学院附属医院妇产科

出　　处：《肿瘤防治研究》2007年第12期944-948,987,共6页Cancer Research on Prevention and Treatment

基　　金：国家重点基础研究发展规划资助项目(2002CB513107);国家自然科学基金资助项目(30528012);海南省教育厅高校科研基金资助项目(HjKj200747)

摘　　要：目的探讨转移抑制基因KAI1/CD82和雌孕激素受体(ER、PR)在子宫内膜癌组织中的表达及与淋巴结转移的关系,并分析其临床意义。方法应用SP法对76例子宫内膜癌组织中KAI1、PR、ER的蛋白表达情况进行观察。结果子宫内膜癌组织中KAI1和PR的阳性表达与手术病理分期、组织学分级、肌层浸润深度呈负相关(PKAIl=0.0089、0.0103、0.0356,PPR=0.0026、0.000、0.0053);伴有盆腔淋巴结转移、宫旁或附件受累及的组织KAI1、PR、ER的阳性表达均明显低于无转移的组织(PKAIl=0.0091、0.0073,PPR=0.0006、0.0074,PER=0.0129、0.0073);ER的阳性表达与FIGO分期呈负相关(P=0.0226);不同的病理类型中,只有PR表达差异有统计学意义(P=0.0446);而三者的表达与患者年龄及宫颈是否受累均无关。KAI1、PR、ER表达阴性和阳性的生存率差异均有统计学意义(PKAIl=0.0043,PPR=0.0010,PER=0.0124)。Logistic回归模型分析结果提示:KAI1、PR、ER三个变量中只有KAI1与淋巴结转移有关(P=0.0400,OR=0.245)。COX比例风险回归模型分析结果显示:KAI1、PR、ER表达均不是子宫内膜癌的独立预后因素。结论KAI1表达与子宫内膜癌的淋巴结转移具有相关性,其可作为临床预测子宫内膜癌患者发生淋巴结转移和评估预后的综合指标之一。KAI1在子宫内膜癌发展中所起的作用可能与PR有关,KAI1、PR、ER的缺失表达与子宫内膜癌的发展、治疗及预后密切相关。Objeetive To investigate the relationship between expressions of tumor metastasis suppressor gene KAI1/CD82, estrogen receptor and progesterone receptor （ER, PR） in endometrial carcinoma tissues and lymph node metastasis, and study the clinical significance of the relationship between them. Methods The expressions of KAI1, PR and ER of 76 cases from Jan. 1998 to Oct. 2005 in Gynecological Tumor Department of Tongji Hospital were studied by irnmunohistochemistry （SP）,and assessed under microscopy and analyzed statistically. Results The expressions of KAI1 and PR in endometrial carcinoma tissues were inverse correlated with surgical-pathologic stage, histological grade and depth of myometrial invasion（PKAH = 0. 0089,0. 0103.0. 0356, PPR = 0. 0026.0. 000,0. 0053） ; the expressions of KAI1. PR and ER in tissues involved in lymph node metastasis, cervix side or adnex were significantly lower than the non-metastasis tissues（PKAH = 0. 0091,0. 0073, PPR = 0. 0006.0. 0074, PER = 0. 0129.0. 0073） ; the expression of ER was inverse related to FICR3 stage of the tissues（P = 0. 0226）. Among different pathological types of tissues, Only the difference in the expression of PR was of statistical significance（P = 0. 0446） ; and the expressions of KAI1,PR and ER were not related to the age of patients and the status of cervix involvement. Under Kaplan Meyer analysis the difference in survival rate was significant statistieally（PKAH = 0. 0043,PPR = 0. 0010,PER = 0. 0124）. Logistic regression analysis showed the expression of KAI1 was related to lymph node metastasis（P = 0. 0400,OR = 0. 245）. The COX proportional hazards regression analysis showed that KAI1, PR and ER were all not the independent prognosis factor to endometrial carcinoma. Conclusion The expression of KAI1 is correlated with the lymph node metastasis, so KAI1 can be used as a predicting indicator of lymph node metastasis and comprehensive assessment in endometrial carcinoma. The important role of KAI1 playing in endometrial carcinoma

关 键 词：子宫肿瘤 KAIL 雌激素受体 孕酮受体 

分 类 号：R737.33[医药卫生—肿瘤]