善宁对大肠癌细胞体外抑制作用探讨  

Exploration of Inhibitory Effect of Sandostain to Colorectal Cancer Cell in vitro

作　　者：李太原[1] 张海涛[2] 端木尽忠[2] 

机构地区：[1]华中科技大学同济医学院,武汉南昌大学第一附属医院430030 [2]南昌大学第一附属医院

出　　处：《肿瘤防治研究》2007年第12期949-951,共3页Cancer Research on Prevention and Treatment

基　　金：江西省卫生厅资助题(J010506)

摘　　要：目的探讨生长抑素(善宁)对体外培养的大肠癌细胞的抑制作用,为大肠癌的内分泌治疗提供实验依据。方法采用MTT法体外检测善宁对54例大肠癌细胞的抑制率。依其性别、年龄、部位、Dukes分期及p53的表达将其分组,统计分析各组病例的敏感药物的差异。结果54例大肠癌病人中有16例对善宁敏感,敏感率为29.6%。善宁敏感性与性别、部位、Dukes分期及p53蛋白的表达无关,但与年龄有关,60岁以下组(敏感率50%)较60岁以上组(敏感率13.3%)敏感,P<0.01。结论善宁在体外对部分大肠癌患者癌细胞有抑制作用,对年轻患者大肠癌细胞抑制作用大于60岁以上患者。Objective In order to provide the experiment evidence of the endocrinotherapy for the patients with colorectal cancer,the inhibitions of the Sandostain to colorectal cancer cell were detected in vitro. Methods The sensitivity of Sandostain to 54 colorectal cancer cases were detected by MTT assay in vitro. Those patients were divided into various groups according to their sex, age, site, Dukes stages and the expression of p53. The sensitivity difference was analyzed by statistics in various groups. Results Sixteen cases were sensitive to Sandostain in 54 patients with colorectal cancer. The rate of sensitivity was 29.6%. There were no relationship between the sensitivities of Sandostain to colorectal cancer cells and their sex, sites, Dukes stages as well as the expression of p53 protein, but the sensitivity of San- dostain was higher in the young group （≤60 y） than in the old group（〉60 y）. Conclusion Sandostain could inhibit cells proliferation in the most part of patients with colorectal cancer,the inhibitory effect of sandostain was stronger in young patients thain in the over 60y patients.

关 键 词：大肠癌 MTT法 体外 胃肠激素 药物敏感试验 

分 类 号：R735.34[医药卫生—肿瘤]