TGF-β1 Snail E-cadherin及N-cadherin在胃癌中的表达及意义  

Expression of TGF-β1,Snail,E-cadherin and N-cadherin in Gastric Cancer and Its Significance

作　　者：祝迎锋[1] 吴继锋[1] 马伟[1] 张红[1] 王道斌[2] 

机构地区：[1]安徽医科大学病理学教研室,合肥市230032 [2]安徽医科大学中心实验室,合肥市230032

出　　处：《中国肿瘤临床》2007年第24期1400-1404,共5页Chinese Journal of Clinical Oncology

基　　金：安徽省教育厅重点科研项目基金资助(编号:kj2007A029)

摘　　要：目的:探讨TGF-β1、Snail、E-cadherin及N-cadherin在胃癌中的表达及意义。方法:采用免疫组织化学法检测96例胃癌组织及80例癌旁组织中TGF-β1、Snail、E-cadherin、N-cadherin的表达,并与临床病理资料做对照分析。结果:胃癌组织中TGF-β1、Snail、E-cadherin及N-cadherin阳性表达率分别为63.5%、83.3%、37.5%、44.8%,癌旁组织分别为28.8%、41.3%、100%、11.3%。四种蛋白在胃癌组织及癌旁组织的表达差异均有显著性(P<0.05)。E-cadherin表达的降低及TGF-β1、Snail、N-cadherin表达的升高与胃癌不同分化程度、组织学类型、浸润深度、淋巴结转移及远处转移有关(P<0.05)。N-cadherin与TGF-β1蛋白的表达呈正相关,并且与E-cadherin的表达呈负相关。E-cadherin与TGF-β1、Snail的表达均呈负相关(P<0.05)。结论:TGF-β1、Snail蛋白的高表达、E-cadherin蛋白的低表达与N-cadherin的反常表达与胃癌的浸润和转移有密切的关系;在胃癌的发展过程中,E-cadherin向N-cadherin转化及TGF-β1、Snail表达可能发挥重要作用。Objective： To investigate the expression of TGF-β1, Snail, E-cadherin and N-cadherin in gastric cancer （GC） and to determine its relationship with malignant features. Methods： The expression of TGF-β1, Snail, E-cadherin and N-cadherin proteins in GC and adjacent tissues were detected by immunohistochemistry, and the correlation with clinicopathological features was analyzed. Results： Positive rates of TGF-β1, Snail, E-cadherin and N-cadherin were 63.5%, 83.3%, 37.5%, and 44.8%, respectively, in GC tissues and 28.8%, 41.3%, 100%, and 11.3%, respectively, in cancer-adjacent tissues, with a significant difference between the two groups （P〈0.05）. The expression rate of these four proteins was related to the differentiation, histological type, depth of invasion, lymph node metastasis and distant metastasis. The expression of N-cadherin was positively correlated with that of TGF-β1 and negatively correlated with that of E-cadherin. E-cadherin expression was negatively correlated with TGF-β1 and Snail expression. Conclusion： The increased expression of TGF-β1 and Snail, the decreased expression of E-cadherin, and the abnormal expression of N-cadherin are involved in the processes of invasion and metastasis of GC. These proteins may play an important role in the development of GC.

关 键 词：胃肿瘤TGF-β1蛋白 SNAIL蛋白 E—cadherin蛋白 N—cadherin蛋白 

分 类 号：R735.2[医药卫生—肿瘤]