PPAR-γ2基因Pro12Ala多态性与肺癌相关性的研究  

The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma 2 gene in lung cancer

作　　者：张宇[1] 钭春凤[1] 毛伟敏[1] 

机构地区：[1]浙江医院肿瘤科,杭州310013

出　　处：《浙江医学》2007年第12期1257-1259,共3页Zhejiang Medical Journal

摘　　要：目的本研究旨在初步探讨过氧化物酶体增殖物激活受体-γ2(PPAR-γ2)基因脯氨酸12丙氨酸(Pro12Ala)多态性与肺癌的关系。方法选择肺癌患者和对照者各45例,收集外周血标本,采用直接测序法检测PPAR-γ2基因Pro12Ala多态性,并进行比较;对两种基因型肺癌患者病理分型、分级及预后指标进行比较,并分析基因型与其相关性。结果两组间PPAR-γ2基因多态性的基因型及等位基因频率分布没有明显的差异;两种基因型肺癌患者病理分型、分级及预后指标差均不明显,无统计学意义(P>0.05),PPAR-γ2基因Pro12Ala多态性与肺癌病理分型、分期及预后指标无相关性。结论PPAR-γ2基因Pro12Ala多态性可能与肺癌的发生、发展及预后无关。Objective To investigate the association of Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma 2 gene （PPAR- γ2） with lung cancer. Methods Forty five patients with stage Ⅲ - Ⅳlung cancer and 45 matched healthy controls were recruited in the study. BMI, performance status and fast glucose were assessed. Genomic DNA samples were extracted from blood. Genotyping was performed using sequencing analysis. Results No significant difference in Pro12Ala polymorphism of PPAR- γ2 gene was found between lung cancer and healthy controls. There was no significant association between Pro12Ala polymorphism and tumor stage or grade （P〉0.05）. Conclusion The Pro12Ala polymorphism does not appear to play a significant role in lung cancer risk.

关 键 词：PPAR-γ2基因肺癌Pro12Ala多态性 

分 类 号：R734.2[医药卫生—肿瘤]