全血5-羟色胺水平与儿童孤独症关系的研究  

The relation between the serotonin level in whole blood and child autism

作　　者：张欣[1] 崔建峰[1] 董伟林[1] 吕丛超[1] 苗汝娟[1] 康静[1] 

机构地区：[1]天津医科大学公共卫生学院儿童少年卫生学教研室,天津300070

出　　处：《天津医科大学学报》2007年第4期497-499,503,共4页Journal of Tianjin Medical University

基　　金：天津市应用基础研究计划面上项目(07JCYBJC10900)

摘　　要：目的:了解全血5-羟色胺水平变化与孤独症患儿的生理状况及其行为的关系,为儿童孤独症的病因及治疗提供线索。方法:对35名特殊托儿机构儿童和56名正常儿童使用克氏孤独症行为量表、克氏孤独症评定量表及ICD-10进行孤独症的筛查、诊断,使用高压液相色谱电化学检测法测定全血5-羟色胺水平,结果使用卫生统计学方法进行分析。结果:18名孤独症患儿和56名正常儿童的全血5-羟色胺水平分别为(228.68±103.44)ng/ml和(137.46±83.63)ng/ml,两组差别有统计学意义(t=3.795,P<0.01);在孤独症患儿中全血5-羟色胺高浓度(>200 ng/ml)的比例最高占61.1%,正常组只占28.6%。经多元回归分析,孤独症患儿的全血5-羟色胺水平与血清铁呈正相关、与血清锌和年龄呈负相关。结论:全血5-羟色胺水平可能是孤独症的一项生物标志。Objective： To observe the relations of 5-HT level in whole blood and physiological state and the behavioral character in the children with autism and provide the clue for the cause and the treatment of autism. Methods：In 35 children in two special education kindergartens and 56 children in a normal kindergarten child autism was screened and diagnosed by using, the Clancy Autism Behavior Scale （CABS）, Childhood Autism Rating Scale（CARS）, Autism Behavior Checklist （ABC）and ICD-10. The whole blood 5- HT was measured by high pressure liquid chromatography （HPLC）-electrochemistry examines. Results：The level of whole blood 5-HT in 15 children with autism and 56 normal children were （228.68±103.44）ng/ml and （137.46±83.63）ng/ml respectively, the differences had statistics significance. The proportion of 5-HT high concentration （〉200 ng/ml） in patients was 61.1% and in normal children was 28.6 %. Using multiple regression analysis, it is the positive correlation in whole blood 5-HT level and serum ferrum iron, and the negative correlation in whole blood 5-HT level and serum zinc and age in the children with autism. It was associated with high 5-HT level in whole blood and the behaviors, etc. Conclusion： 5-HT level may be a biological indicator of autism.

关 键 词：5-HT 全血 儿童孤独症 

分 类 号：R749.94[医药卫生—神经病学与精神病学]