丙氨酰谷氨酰胺注射液对食管癌患者术后营养和免疫状况的影响  

Effect of Glutamine Dipeptides on the Postoperative Nutrition and Immunofunction of Patients with Esophagus Carcinoma

作　　者：赵劲松[1] 廖克龙[1] 杨康[1] 张伟[1] 熊刚[1] 李军[1] 谭文峰[1] 

机构地区：[1]第三军医大学附属西南医院胸心外科,重庆400038

出　　处：《中国临床营养杂志》2007年第6期347-350,共4页Chinese Journal of Clinical Nutrition

基　　金：吴阶平医学基金会华瑞力太临床科研项目(AWSGCT2006)

摘　　要：目的评估丙胺酰谷氨酰胺注射液对食管癌患者术后营养和免疫状况的影响。方法将100例食管癌患者随机分为研究组和对照组,均于术后给予7天全胃肠外营养(TPN),其中研究组按每天0.4g/kg的剂量加用丙胺酰谷氨酰胺注射液。分别于术前,术后第2天、第6天检测所有患者的血清白蛋白水平、T细胞亚群、IgA、IgG、IgM,及术前、术后的体重指数。结果研究组患者的血清白蛋白、IgA、IgG及体重指数在术后第6天分别为(42.8±3.4)g/L、(2.7±2.2)g/L、(10.8±2.2)g/L和(19.1±1.6)kg/m2,明显高于对照组的(36.3±2.5)g/L、(2.1±2.7)g/L、(8.0±1.4)g/L和(16.8±1.0)kg/m2(P均<0.05)。结论食管癌患者术后在常规TPN治疗基础上加用丙胺酰谷氨酰胺注射液可以改善营养和免疫状况。Objective To evaluate the effect of glutamine dipeptides-enhanced parenteral nutrition on the postoperative nutrition and immunofunction of patients with esophagus carcinoma. Methods One hundred patients with esophagus carcinoma were randomly divided into Gin group and control group. All patients were administered with parenteral nutrition for seven days, and patients in Gin group were simultaneously added with alanyl glutamine solution （0.4 g/kg per day）. The serum album （ALB） level, T lymphocyte subgroups, IgA, IgG, IgM, and body mass index （BMI） were measured. Results The ALB level, IgA, IgG, and BMI were （42.8 ± 3.4） g/L, （2.7±2.2） g/L, （10.8 ±2.2） g/L, and （19.1 ±1.6） kg/m^2 in Gin group on the sixth postoperative day, which were significantly higher than those in control group （ All P 〈 0. 05 ）. Conclusion Alanyl glutamine solution-enhanced TPN therapy can improve the postoperative nutrition and immunofunction in patients with esophagus carcinomas.

关 键 词：食管癌 全胃肠外营养 谷氨酰胺 体重指数 

分 类 号：R735.1[医药卫生—肿瘤]