定量药物脑电图预测氯氮平对精神分裂症的疗效  

Quantitative pharmaco EEG predicting the curative effect of clozapine in schizophrenia

作　　者：吕路线[1,2,3] 尚景瑞[1,2,3] 郭素芹[1,2,3] 郭云 康来应[1,2,3] 尹景岗 侯永华[1,2,3] 

机构地区：[1]河南省精神病医院 [2]中山医科大学 [3]河南省新乡市职业病防治研究所

出　　处：《中华精神科杂志》1997年第3期153-156,共4页Chinese Journal of Psychiatry

摘　　要：为了探讨氯氮平对精神分裂症病人脑电活动的影响，预测该药的近期临床疗效，应用定量药物脑电图（ＱＰＥＥＧ）方法对６３例精神分裂症病人进行了自身前后的对照研究。结果显示，口服一次量２５ｍｇ氯氮平后，精神分裂症Ⅰ型病人Ｏ１导联α２频段能量在服药后第５小时较服药前显著降低（Ｐ＜０．０５），Ｆ４导联δ频段能量在第５小时较服药前显著增高（Ｐ＜０．０５），Ｆ３导联β频段能量有增高趋势，但未达到显著水平。精神分裂症Ⅱ型病人Ｏ２导联α２频段能量在第４小时较服药前显著降低（Ｐ＜０．０５），Ｆ４导联δ频段及Ｆ３导联β频段能量有增高趋势，但未达到显著水平。出现上述脑电变化者临床疗效好，反之则临床疗效差。判别分析结果显示，ＱＰＥＥＧ对氯氮平近期临床疗效的预测基本可靠，预测分组正确率为８６％～１００％。In order to investigate the effect of clozapine on the brain electrical activity of schizophrenics and predict the short term clinical curative effect of this drug, the pre post control studies were made by recording quantitative pharmaco EEG (QPEEG) in 63 schizophrenics. It was found that in type I schizophrenia, the α 2 band energy of O 1 lead was significantly lower at 5th hour after taking one 25 mg clozapine than that of pre treatment ( P <0.05), δ band one of F 4 lead significantly higher ( P <0.05), β band energy of F 3 lead had a trend of increase, but less than significant level; as for type Ⅱ, the α 2 band energy of O 2 lead was obviously lower at 4th hour than that of pre treatment ( P <0.05), both the δ band energy of F 4 lead and β band energy of F 3 lead had the trend of increase, but none of them reach the significant level. The patients who had the changes as showed above would have a better clinical curative effect than who didn′t have such changes. The result of distinguishing analysis shows that it is credibility of use QPEEG to predict the short term clinical curative effect of clozapine, and the correct rate of predicting group is 86%—100%.

关 键 词：精神分裂症 氯氮平 脑电图 预测 

分 类 号：R749.305[医药卫生—神经病学与精神病学] R971.4[医药卫生—临床医学]