慢性闭角型青光眼与正常眼压性青光眼视盘形态比较  

A comparative study of optic nerve damage between chronic angle closure glaucoma and normal tension glaucoma

作　　者：赵琳[1] 吴玲玲[1] 王欣[1] 

机构地区：[1]北京大学第三医院；北京大学眼科中心,北京100083

出　　处：《中国实用眼科杂志》2007年第12期1283-1287,共5页Chinese Journal of Practical Ophthalmology

摘　　要：目的探讨眼压依赖型与非眼压全依赖型青光眼患者视盘损害的形态异同。方法用回顾性配对设计研究。选择具有青光眼性视野缺损（MD〈10dB）的慢性闭角青光眼（CACG）和正常眼压青光眼（NTG）患者各20例20眼,年龄、视野平均偏差（mean deviation,MD）一对一相匹配。应用海德堡视网膜断层扫描仪（HRT-Ⅱ）进行定量视盘参数检查,并对检查结果进行比较。结果CACG组视盘总体和颞下、鼻下、鼻上分区的盘沿面积大于NTG组;差异有统计学意义（P〈0.05）;CACG组视盘总体和各分区（除颞侧外）视杯容积小于NTG组,两组间差异均有统计学意义（P〈0.05）;CACG组视盘总体和各分区（除颞侧及颞下外）视杯平均深度及视杯形态测量值小于NTG组,两组间差异均有统计学意义（P〈0.05）。结论CACG与NTG在疾病早中期视盘形态明显不同,提示眼压依赖型与非眼压全依赖型青光眼可能具有不同的视神经病变发生机制。Objective To investigate the differences in the morphology of optic nerve damage in patients with intraocular pressure-dependent glaucoma and non-dependent intraocular pressure glaucoma. Method This is retrospective paired design study. We attempted to match 20 patients （20 eyes） in the CACG group on the age and visual field mean deviation case-by-case basis with comparable 20 patients （20 eyes） in NTG group. Heidelberg Retina Tomograph Ⅱ was used to evaluate the optic nerve head, and the parameters were compared. Results The total, temporal/interior, nasal/superior and nasal/interior rim area of optic disc were significantly larger in patients with CACG than NTG （P〈0.05）. Total cup volume and sectors except temporal quadrant of optic disc were significantly （P〈0.05） smaller in patients with CACG than NTG. Total mean cup depth and cup shape measure and sectors except temporal and temporal/interior quadrant of optic disc were significantly （P〈0.05） smaller in patients with CACG than NTG. Conclusion Significant differences were found in the early and mid-stage patients between CACG and NTG, and it suggest that the intraocular pressure-dependent and non-dependent intraocular pressure in glaucoma may have different mechanisms of optic neuropathy.

关 键 词：青光眼 海德堡视网膜断层扫描仪 视盘 

分 类 号：R775.2[医药卫生—眼科]