Wnt信号通路抑制因子SFRP1在肿瘤中的研究进展  

Progress in Wnt Signal Pathway Antagonists SFRP1 in Cancer

作　　者：郑枫芸[1] 李继承[1] 

机构地区：[1]浙江大学细胞生物学研究所,杭州310058

出　　处：《细胞生物学杂志》2007年第6期805-808,共4页Chinese Journal of Cell Biology

摘　　要：定位于染色体8p11.2上的分泌型卷曲相关蛋白1(secreted frizzled related protein 1,SFRP1)基因,是近来发现的新的抑癌基因。因其编码Wnt信号通路抑制因子SFRP1,SFRP1基因失活可导致Wnt信号转导途径的紊乱,影响肿瘤的发生发展。近年来国内外对SFRP1在恶性肿瘤的失活机制进行了一系列的研究,现对这方面的工作进展进行综述。The secreted frizzled related protein 1 （SFRP1） gene, which is located on chromosome 8p11.2, has recently been demonstrated to be a new tumor suppressor gene. Since SFRP1 gene encodes a Wnt signaling antagonist, it causes deregulation of Wnt signaling by inactivation, and finally affects human tumorigenesis and progression. A series of researches about the inactive mechanism of SFRP1 in human malignancies have been done in recent years, and now we review them in this article.

关 键 词：肿瘤 WNT信号通路 分泌型卷曲相关蛋白1 

分 类 号：R730.2[医药卫生—肿瘤]