胶质细胞与病理性疼痛  

Glia and Pathological Pain

作　　者：孙珊[1] 高俊鹏[1] 吕宁[2] 蔡定芳[1] 

机构地区：[1]复旦大学附属中山医院中西医结合科,上海200032 [2]复旦大学神经生物学研究所,上海200032

出　　处：《细胞生物学杂志》2007年第6期826-830,共5页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(No.30600178;No.30570594);长江学者和创新团队发展计划资助项目~~

摘　　要：胶质细胞是中枢神经系统内的一类有别于神经元的细胞,可表达多种神经递质或细胞因子受体,在神经系统的多种功能中扮演着重要角色。组织损伤或炎症引起脊髓胶质细胞大量激活,激活的胶质细胞分泌多种细胞因子和神经-胶质兴奋物质,参与病理性疼痛的产生与维持。以胶质细胞为靶点可能为病理性疼痛的治疗另辟蹊径。In the central nervous system, glial cells play an important role in the development and maintenance of central sensitization. Glial cells express many receptors of neurotransmitters and cytokines. Robust glial activation has been observed on the lumbar spinal cord in various rodent models of chronic pain. The degree and time course of glial activation are correlated with pain facilitation. Activated spinal glia release a variety of algesic substances, such as pro-inflammatory cytokines, which enhance pain transmission. Glial cells will be targeted in order to kill pathological pain.

关 键 词：胶质细胞 细胞因子 疼痛 痛觉过敏 触诱发痛 

分 类 号：R363[医药卫生—病理学]