树突状细胞来源的Exosomes的免疫调节作用  

Immunoregulatory Role of Dendritic Cell-derived Exosomes

作　　者：刘袁媛[1] 范华骅[1] 陈亮[1] 

机构地区：[1]上海市血液中心血液工程研究室

出　　处：《细胞生物学杂志》2007年第6期845-848,共4页Chinese Journal of Cell Biology

基　　金：上海市科委基金资助(No.05XD14029)~~

摘　　要：Exosomes是多种细胞经晚期内体形成的一种膜性小囊泡。最初认为其功能仅为降解内吞物质,但研究发现exosomes的特异功能与其来源细胞相关,尤其是抗原提呈细胞(APCs)——树突状细胞来源的exosomes(dendritic cell-derived exosomes,DEXs)集MHC-I/MHC-II、共刺激分子、黏附分子、热休克蛋白于一身,在体内外免疫调节中起非常重要的作用。现对DEXs诱导抗肿瘤免疫应答和诱导免疫耐受两方面的功能及可能的免疫调节机制进行综述。Exosomes are small vesicles that form within late endocytic compartments by various cell types. In addition to the original function of discarding the uselessful membrane molecules, exosomes are involved in a range of immunoregulatory functions in vivo and in vitro, especially dendritic cell-derived exosomes （DEXs） which richly contain MHC-Ⅰ/MHC-Ⅱ, costimulatory molecules, adhesion molecules and heat shock proteins. Potent antitumor effect and induction of immune tolerance by DEXs are addressed in this review.

关 键 词：EXOSOMES 树突状细胞 抗肿瘤 免疫耐受 

分 类 号：R392[医药卫生—免疫学]