Effects of 5-hydroxytryptamine ascending pathways of dorsal raphe nuclei and habenular nucleus on the respiration and blood pressure of rats  

作　　者：YU Lei HUANG Min XU Hai-yan ZHAO Hua 

机构地区：[1]Department of Physiology, School of Basic Medical Sciences, JilinUniversity, Changchun 130021, China

出　　处：《Chinese Medical Journal》2007年第24期2308-2310,共3页中华医学杂志（英文版）

基　　金：This study was supported by a grant from the National Natural Science Foundation of China(No.30270502)

摘　　要：Obstructive sleep apnea syndrome （OSAS） was a disease of breath obstacle happened in the process of sleep. The central mechanism of OSAS has not yet been fully elucidated. Most of studies focused on raphe nuclei and 5-hydroxytryptamine （5-HT）, and showed that brain serotonergic activity might be decreased in OSAS. It is well known that the dorsal and medial raphe nuclei provide almost all the serotonergic innervation to the forebrain. A previous study evaluated the stimulation of the dorsal raphe nuclei （DRN） in the rat inducing mainly pressor and sympathoexcitatory responses.Obstructive sleep apnea syndrome （OSAS） was a disease of breath obstacle happened in the process of sleep. The central mechanism of OSAS has not yet been fully elucidated. Most of studies focused on raphe nuclei and 5-hydroxytryptamine （5-HT）, and showed that brain serotonergic activity might be decreased in OSAS. It is well known that the dorsal and medial raphe nuclei provide almost all the serotonergic innervation to the forebrain. A previous study evaluated the stimulation of the dorsal raphe nuclei （DRN） in the rat inducing mainly pressor and sympathoexcitatory responses.

关 键 词：habenular nucleus dorsal raphe nuclei RESPIRATION blood pressure LIDOCAINE 5-HYDROXYTRYPTAMINE 

分 类 号：R971.2[医药卫生—药品]