LFTP序贯每周方案与ECF方案治疗晚期胃癌的比较研究  

Clinical study of sequential weekly dose of 5-fluoro-2'-deoxyuridine with leucovorin, docetaxel, cisplatin contrast with ECF regimen for advanced gastric cancer

作　　者：洪专[1] 冯继锋[1] 陈嘉[1] 陈环球[2] 周兆飞[1] 潘良熹[1] 黄富麟[1] 郑秀立[1] 

机构地区：[1]江苏省肿瘤医院内科,南京210009 [2]江苏省肿瘤医院普外科,210009

出　　处：《临床肿瘤学杂志》2007年第12期933-935,937,共4页Chinese Clinical Oncology

摘　　要：目的:观察比较LFTP方案与ECF方案治疗晚期胃癌的客观疗效及毒副反应。方法:56例Ⅳ期胃癌随机分成两组。LFTP方案组27例,采用亚叶酸钙(CF)100mgiv,d1、d8、d15;氟苷(FUDR)500mg/m2iv维持6小时,d1、d8、d15;多西紫杉醇(DTX)35mg/m2iv维持1小时,d2、d9、d16;顺铂(PDD)30mg/m2iv,d3、d10、d17。ECF方案组29例,采用CF100mgivd1～d5;氟尿嘧啶(5-FU)500mg/m2iv维持6小时,d1～d5;表阿霉素(EPI)50mg/m2iv,d2;PDD30mg/m2iv,d3～d5。两组均4周为1个周期,2周期后按照WHO标准统一评定疗效及毒副反应。结果:LFTP组:CR0例,PR16例,NC9例,PD2例,有效率为59.3%(16/27),PD率7.4%(2/27);ECF组:CR0例,PR15例,NC4例,PD10例,有效率为51.7%(15/29),PD率34.5%(10/29)。两组有效率比较无显著性差异(P=0.1814),LFTP组PD率明显低于ECF组(P=0.0126)。两组毒副反应多表现为Ⅰ～Ⅱ度,其中口腔炎LFTP组29.7%(8/27)、ECF组55.2%(16/29),LFTP组低于ECF组(P=0.0346);腹泻LFTP组25.9%(8/27)、ECF组55.2%(15/29),LFTP组低于ECF组(P=0.0321)。结论:LFTP方案较ECF方案治疗晚期胃癌的近期疗效较好,毒副反应可以耐受,值得进一步研究。Objective：To evaluate the objective anti-tumor efficacy and safety of sequential weekly dose of floxuridine （FUDR） with leucovorin, docetaxel, cisplatin contrast with ECF regimen for advanced gastric cancer. Methods：Fifty-six cases of advanced gastric cancer were divided into 2 groups, LFTP group and ECF group. LFTP group used CF 100mg iv d1,d8,d15, FUDR 500mg/m^2 iv d1,d8,d15, docetaxel 35mg/m^2 iv d2,d9,d16, cisplatin 30mg/m^2 iv d3,d10,d17. ECF group used CF 100mg iv d1-d5, 5-FU 500mg/m^2 iv d1-d5, EPI 50mg/m^2 iv d2, cisplatin 30mg/m^2 iv d3,d4,d5, this regimen was repeated every 4 weeks. All the patients were received 2 cycles. Results：LFTP group： 59.3%（16/27）of response rate were achieved with PD 7.4%（2/27）,in all 27 cases; ECF group： 51.7%（15/29） （P=0.181 4） of response rate were achieved with PD 34.5%（10/29） （P=0.012 6） in all 29 cases. The major toxicity included mucositis, diarrhea, phlebitis, nausea vomiting, neutropenia. Among side effects mucositis was the most common seen. Most were grade Ⅰ-Ⅱ which were tolerable for all patients. Conclusion：The regimen was an effective chemotherapy for advanced gastric cancer, the adverse reactions were not severe, further clinical study should be warranted.

关 键 词：晚期胃癌 氟尿嘧啶脱氧核苷 多西紫杉醇 顺铂 化学疗法 

分 类 号：R730.53[医药卫生—肿瘤] R735.2[医药卫生—临床医学]