非小细胞肺癌组织和支气管切缘环氧化酶-2活性表达的研究  

Expression of COX-2 activity at resection margin of the bronchus and lung cancer tissues

作　　者：杨帆[1] 马海涛[1] 朱建军[1] 黄海涛[1] 

机构地区：[1]苏州大学附属第一医院胸心外科,江苏苏州215006

出　　处：《世界肿瘤杂志》2007年第4期245-247,252,共4页Tumour Journal of the World

摘　　要：目的研究非小细胞肺癌组织和支气管切缘环氧化酶．2（Cyclooxygenase，COX-2）活性表达的意义及其与预后的关系。方法应用RT-PCR技术检测80例非小细胞肺癌组织、支气管切缘（支气管切缘病理切片无癌组织残留）及12例肺部良性病变组织的COX．2活性。结果在80例肺癌组织中，COX-2活性表达为58．8％（47例），切缘COX-2活性表达为12．5％（10例）。10例肺良性病变组织中未发现COX-2阳性表达。癌组织COX-2活性与肺癌肿瘤大小、临床分期、病理分化程度、病理组织分型、淋巴结转移以及肿瘤部位显著相关。支气管切缘COX-2活性与肺癌肿瘤大小、临床分期及肿瘤部位有显著性相关。术后随访6mo-3a，共有9例残端复发，其中8例为支气管切缘COX-2活性阳性病人。结论COX-2活性表达与非小细胞肺癌发生、进展和预后有关，检测肺切缘COX-2活性可作为早期预测肺癌术后复发的重要依据。Objeetive To study the expression of COX-2 activity at resection margin of the bronchus and lung cancer tissues, and to predict cancer recurrence. Methods The expression of COX-2 activity at patients with non small-cell lung cancer and 10 patients with non-cancerous diseases by RT-PCR technique. Results The positive expression rates of COX-2 activity at resection margin of the bronchus and lung cancer tissues were 12.5% （10 cases） and 58.8% （47cases）, respectively. Those of COX-2 activity in lung non-cancerous tissues were negative. The positive expression rates of COX-2 activity in cancer tissues correlated with tumor size, TNM stages, pathological differentiation level, histological typeing, lymphatic metastasis, and tumor location （P〈0.05）. The positive expression of COX-2 activity at resection margin of the bronchus correlated with tumor size, TNM stages and tumor location （P〈0.05）. During follow-up period （ranged 6 months to 3 years）, 8 patients with COX-2 activity at resection margin had local recurrence. Conclusions The expression of COX-2 activity correlated with genesis, progression and prognosis of esophageal cancer. By testing COX-2 activity at resection margin of the bronchus, we may predict local recurrence of lung cancer.

关 键 词：非小细胞肺癌 支气管切缘 环氧化酶-2 

分 类 号：R73-33[医药卫生—肿瘤] R734.2[医药卫生—临床医学]