枕叶陈旧性梗死后视放射Wallerian变性的MR-DTI研究  

MR-DTI Study on Wallerian Degeneration of the Optic Radiation after Occipital Lobe Chronic Infarction

作　　者：宛四海[1] 张雪林[1] 孙鑫[2] 肖新兰[2] 邢海芳[3] 

机构地区：[1]南方医科大学南方医院影像中心,广东广州510515 [2]南昌大学第二附属医院磁共振室 [3]通用电器公司中国医疗集团

出　　处：《实用放射学杂志》2007年第12期1585-1587,共3页Journal of Practical Radiology

摘　　要：目的探讨磁共振扩散张量成像(DTI)检测和定量分析枕叶梗死后视放射Wallerian变性的可行性。方法对20例单侧枕叶陈旧性梗死的患者进行了DTI研究,分别测量双侧视放射的部分各向异性(FA)和平均弥散量(MD)。应用独立样本t检验确定双侧差异有无显著性。结果在三维彩色编码张量FA图上,枕叶陈旧性梗死区呈低信号,患侧视放射呈低信号,FA值及MD值分别为0.274±0.062和(1.226±0.372)×10-3mm2/s,健侧视放射FA值及MD值分别为0.495±0.035和(0.775±0.070)×10-3mm2/s,双侧比较二者均有明显显著性差异(P(0.01)。结论DTI可以检测并定量分析枕叶陈旧性梗死后视放射的Walleri-an变性。Objective To evaluate the possibility of diffusion tensor imaging（DTI） in detecting and quantifying the Wallerian degeneration of optic radiation in occipital lobe chronic infarction. Methods 20 patients with unilateral occipital chronic infarction were undergone DTI. Quantitative fractional anisotropy （FA）and mean diffusivity （MD） were obtained from the ipsilateral optic radiation of the occipital lobe infarction and compared with that of contralateral region using the independent samples t - test. Results On the three dimensional color - coding tensor fractional anisotropic map, the regions of occipital lobe chronic infarction were markedly low signal intensity,the FA value and MD value were 0. 274 ± 0. 062 and （ 1. 226 ± 0. 372 ） ×10 ^-3 mm^2/s, while in the contralateral region of optic radiation, FA and MD values were 0. 495 ±0. 035 and （0. 775 ± 0. 070 ） × 10^-3 mm^2/s respectively, there was significant difference in FA and MD values in comparing both side（ P 〈 0. 01 ）. Conclusion DTI can detect and quantify the Wallerian degeneration in optic radiation after occipital lobe chronic infarction.

关 键 词：视放射 脑 沃勒变性 扩散张量成像 

分 类 号：R743[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]