尼莫地平透皮吸收的体外研究  

In Vitro Study on the Transdermal Effect of Nimodipine-loaded Ointment with PLEG6000 as Permeation Enhancer

作　　者：周辰[1] 范盈[1] 刘文胜[1] 

机构地区：[1]首都医科大学化学生物学与药学院,北京100069

出　　处：《中国医药导刊》2007年第6期504-505,共2页Chinese Journal of Medicinal Guide

基　　金：北京市属市管高等学校人才强教计划项目(3500107508)

摘　　要：目的:研究聚乳酸-聚乙二醇嵌段共聚物6000(PLEG6000)对软膏剂中尼莫地平的促透效果。方法:以PLEG6000作为促透剂,制备不同载药量的尼莫地平软膏剂,并对其累积透过量、稳态透皮速率、透皮时滞及PLEG6000促透效果进行研究和分析。结果:相同促透剂条件下,尼莫地平软膏剂载药量在30～45mg/g时透皮效果较好;PLEG6000对尼莫地平软膏剂的促透作用比Azone略强。结论:实验结果表明,采用PLEG6000作为促透剂所制备的尼莫地平软膏剂具有良好的透皮效果。Objective： Nimodipine - loaded transdennal ointment was prepared, the transdennal enhancing effect of PLEG6000 was evaluated. Methods： Nimodipine - loaded ointment was prepared with PLEG6000 as permeation enhancer, the percutaneous parameters（Q, J and Tlag） and the permeation enhancing effect of PLEG6000 was mensttrated through rats skin.Results： The transdennal effect of nimodipine - loaded ointment was better when the loading amount was among 30 - 45 mg/g. The enhancing effect of PLEG 6000 to nimodipine - loaded ointment was slightly better than Azone.Conclusions： The transdermal ability of the prepared nimodipine - loaded ointment was favorable when using PLEG6000 as an effective permeation enhancer.

关 键 词：聚乳酸-聚乙二醇嵌段共聚物 尼莫地平 透皮制剂 促透剂 

分 类 号：R94[医药卫生—药剂学]