原发性甲状腺鳞状细胞癌  

Primary squamous cell carcinoma of thyroid gland

作　　者：刘菲[1] 郑宏良[1] 陈世彩[1] 王素敏[1] 周义德[1] 

机构地区：[1]第二军医大学长海医院耳鼻咽喉头颈外科,上海200433

出　　处：《中国耳鼻咽喉头颈外科》2007年第12期691-693,共3页Chinese Archives of Otolaryngology-Head and Neck Surgery

摘　　要：目的探讨原发性甲状腺鳞状细胞癌的临床特征和综合治疗效果。方法回顾性分析我院1993～2003年收治甲状腺鳞状细胞癌患者3例,介绍其临床特点和诊疗方法,结合文献进行分析。结果3例原发性甲状腺鳞状细胞癌主要临床表现为颈部肿块伴呼吸困难、吞咽困难和声音嘶哑等症状,就诊时病程1个月～1年。检查发现甲状腺区域肿瘤质硬,活动度差,边界不清。辅助检查提示病变侵犯食管及喉、气管等周围组织。均行扩大甲状腺癌根治及颈清扫术,其中食管部分切除直接修补1例;开胸后喉、喉咽、食管全部切除加胃咽吻合术1例;颈段气管袖状切除端端吻合,复发后给予喉全及喉咽全切,气管、食管部分切除游离空肠修复1例。术后2例予以放疗及化疗,分别存活8个月和带瘤生存5年2个月,术后未放疗的1例存活2个月。结论甲状腺鳞状细胞癌是一种罕见的恶性肿瘤,病情发展迅速,预后极差。如能尽早发现并进行扩大根治性手术,并辅以足量放疗及化疗,能最大限度提高患者生存率。OBJECTIVE To explore the clinical feature and combined modality treatment of primary squamous cell carcinoma of thyroid gland （SCCT）. METHODS Three patients with SCCT were treated in our hospital from 1993 to 2003. The clinical features and the therapeutic methods of these cases were analyzed, and the literature was reviewed. RESULTS The main clinical presentations included neck masses, dyspnea, dysphagia, hoarseness. A hard and fixed mass at the thyroid gland area was often found in these cases. All the cases underwent extended radical resection and neck dissection, and received postoperative radiotherapy and chemotherapy because the adjacent tissues were invaded. The three patients survived for 2, 8 months, and 5 year and 2 months （up to now） respectively. CONCLUSION SCCT is a rare malignant tumor and it progresses rapidly. Early diagnosis, radical resection, full-dose postoperative radiotherapy and chemotherapy are vital for a long survival period.

关 键 词：甲状腺 癌 鳞状细胞 

分 类 号：R736.1[医药卫生—肿瘤]