BRMS1在胃癌组织中的表达与淋巴结转移的关系  

Relationship between the expression of BRMS1 mRNA and the metastasis of lymph node with gastric carcinoma

作　　者：彭海[1] 周文学[1] 周昊昕[1] 李云龙[1] 邹小明[1] 

机构地区：[1]哈尔滨医科大学附属第二医院胃肠外科,黑龙江哈尔滨150086

出　　处：《中国现代普通外科进展》2007年第6期497-499,共3页Chinese Journal of Current Advances in General Surgery

摘　　要：目的:探讨胃癌组织中乳腺癌转移抑制基因(breast cancer metastasis suppressor1,BRMS1)mRNA表达水平与胃癌淋巴结转移之间的关系。方法:根据胃癌淋巴结转移情况,将66例胃癌标本分为转移组(46例)和未转移组(20例);以β-actin为内参照,用半定量RT-PCR方法检测66例胃癌组织中BRMS1 mRNA的表达。结果:BRMS1 mRNA在胃癌组织中的表达为0.441±0.096;BRMS1 mRNA在胃癌淋巴结转移组和未转移组中的表达分别为0.405±0.072、0.525±0.091,转移组BRMS1 mRNA的表达水平显著低于未转移组(P<0.05)。结论:BRMS1 mRNA在胃癌组织中的表达水平与淋巴结转移呈负相关,而与病理类型、分化程度无相关性。Objective： To study the relationship between the expression of breast cancer metastasis-suppressor 1 （BRMS1） mRNA and the metastasis of lymph node with gastric carcinoma. Methods： According to the metastasis of lymph node, 66 cases were divided into metastasis of lymph node group （n=46） and no metastasis of lymph node group （n=20）. The expression of BRMS1 mRNA was determined by Semi-RT-PCR method （with reference β-actin）. Results： The expression of BRMS1 mRNA was 0.441 ± 0.096 in gastric neoplasms, and it was 0.405± 0.072 and 0.525± 0.091 respectively in metastasis of lymph node and no metastasis of lymph node. It was significantly lowered in metastasis group （P 〈 0.05）. Conclusion： There was a negative relationship between the expression of BRMS1 mRNA and the metastasis of lymph node in gastric neoplasms; but was not correlated with the pathological type or split up degree.

关 键 词：胃肿瘤 转移抑制基因 淋巴结 转移 

分 类 号：R733.7[医药卫生—肿瘤]