子宫内膜癌中MTA1蛋白表达水平的研究  

Expression of MTA1 Protein in Carcinoma of Endometrium

作　　者：潘九林[1] 韩素萍[1] 

机构地区：[1]南京医科大学,江苏南京210009

出　　处：《实用临床医药杂志》2007年第6期32-34,共3页Journal of Clinical Medicine in Practice

摘　　要：目的探讨肿瘤转移相关基因1(MTA1)蛋白表达与子宫内膜癌生物学行为之间的关系。方法采用免疫组化SP法检测18例正常宫内膜,48例宫内膜癌中MTA1蛋白的表达水平,并分析其与临床病理特征的关系。结果子宫内膜癌中MTA1蛋白的阳性表达率(64.58%)明显高于正常宫内膜(5.56%)(P<0.001),其中,雌激素受体阴性组的表达高于阳性组(P<0.001)。低分化的宫内膜癌,较之中、高分化者,有更高水平的MTA1蛋白表达(P=0.001),有肌层浸润组的蛋白表达率高于无肌层浸润组(P=0.017)。未发现MTA1蛋白的表达与宫内膜癌临床分期、淋巴结转移有关。结论MTA1蛋白的过表达在子宫内膜癌的发生、组织浸润过程中可能起一定的作用,其阳性表达与雌激素受体阴性的宫内膜癌关系更密切。MTA1蛋白有望成为子宫内膜癌基因治疗的新靶点。Objective To investigate the relationship between MTA1 protein expression and biological behavior of endometrial carcinoma. Methods MTA1 expression and it＇s relation to clinico -pathological features were examined in 18 normal endometriumtissues, and 48 carcinoma of endometrium were examined by immunohistochemical sp method. Results the positive expression rate of mtal in carcinoma of endometrium was 64.58 % which was significantly higher than that of the control group 5.56% （P〈0. 001）. The estrogen receptor （ER） negative group showed higher expression rate than that of the ER positive group （P〈 0. 001）. The difference of the expression of mtal protein among different grades of histological differentiation was significant （ P = 0.01） and the finding were similar between the group of intramuscular infiltration and the group of nonintra-muscular infiltration （P = 0. 017）. the relationship of MTA1 protein with clinical the stages and lymph node involvement were not found. Conclusion The overexpression of MTA1 might play a role in the pathogenesis and development of carcinoma of endometrium. The positive expression of mtal protein was closely related to the ER negative endometrial carcinoma. MTA1 has promise of becoming a novel target for endometrial carcinoma gene therapy.

关 键 词：MTA1蛋白 子宫内膜癌 免疫组化 雌激素受体 

分 类 号：R737.33[医药卫生—肿瘤]