茶多酚联合重组人血管内皮抑制素(恩度)对人肺腺癌A549抑制作用研究  

The Combination of Tea polyphenols and Recombinant Human Endostatin Injection (Endostar) Inhibits Xenografted Tumor Growth of Human Lung Adenocarcinoma A549

作　　者：马成杰[1] 李元青[1] 刘朝阳[2] 陈信义[1] 孙颖立[1] 

机构地区：[1]北京中医药大学东直门医院肿瘤血液科,教育部,北京市中医内科学重点实验室,北京100700 [2]中国医学科学院肿瘤研究所,北京100021

出　　处：《中国中医药信息杂志》2008年第1期41-43,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金资助(30472280)

摘　　要：目的观察茶多酚联合重组人血管内皮抑制素对人肺腺癌生长抑制作用,为进一步深入研究茶多酚抗肿瘤血管生成机制提供依据。方法人肺腺癌(A549)细胞系经传代培养后,移植于BALB/c-nu祼鼠,以茶多酚、重组人血管内皮抑制素(恩度)及其联合用药干预治疗,通过观察肿瘤抑制率评价单用与联合用药对A549生长抑制作用。结果茶多酚、恩度以及茶多酚联合不同剂量恩度的肿瘤抑制率分别为40.2%、35.8%、41.9%和44.2%,与模型组比较,具有统计学意义(P<0.01);治疗各组间比较,无统计学意义(P>0.05)。结论茶多酚、恩度及其联合用药对A549均有明显的抑制效果;茶多酚与恩度联合使用增效作用不明显。Objective To observe the suppression of human lung adenocancer growth to tea polyphenols plus Recombinant Human Endostatin Injection （Endostar）. To offer the foundation which tea polyphenols inhibit angiogenesis effect and research its molecular mechanism. Methods After cultured and propagation, human lung adenocancer of A549 was implanted on BALB/c nude mice. Tea polyphenols, Endostar and drug combinations were taken by intraperitoneal injection. Antitumor function was determined with regular methods. Results The tumor control rate of tea polyphenols group, Endostar group and two drug combination groups were respectively 40.2%, 35.8%, 41.9% and 44.2%. The average tumor weight of four treated groups were all smaller than that of model group （P〈0.01）. The average tumor weight of two drug combination groups was no smaller than that of tea polyphenols group and Endostar group （P〉0.05）. Conclusion Tea polyphenols, Endostar and drug combination had significant inhibition effect on human lung adenocancer, but drug combination had no significant inhibition effect.

关 键 词：茶多酚 重组人血管内皮抑制素(恩度) 人肺腺癌A549 

分 类 号：R285.5[医药卫生—中药学]