2,3-二(2-呋喃)喹喔啉的合成、表征及与ct-DNA的相互作用  

Synthesis,Characterization and Interaction of 2,3-Bis [2-furan]quinoxaline with ct-DNA

作　　者：侯林荣[1] 杨天林[1] 张丽军[1] 

机构地区：[1]宁夏大学能源化工重点实验室,宁夏银川750021

出　　处：《宁夏大学学报（自然科学版）》2007年第4期346-349,353,共5页Journal of Ningxia University(Natural Science Edition)

基　　金：宁夏自然科学基金资助项目(NZ0507);宁夏大学科研基金资助项目

摘　　要：合成了2,3-二(2-呋喃)喹喔啉化合物,通过IR,MS,1HNMR和元素分析进行了结构表征.在pH值为7.25的Tris-HCl缓冲溶液中,采用紫外光谱、荧光光谱和黏度法研究了2,3-二(2-呋喃)喹喔啉与ct-DNA的相互作用.结果表明,该化合物以插入模式与ct-DNA键合,结合常数K=6.02×104L/mol,结合位点为1.07.In this paper, a novel 2, 3-bis [2-furan] quinoxaline was synthesized, and its structure has been characterized by IR,MS,^1HNMR and the elements analysis. The interaction between 2,3-bis [2-furan]quinoxaline and ct-DNA has been studied by electronic absorption spectroscopy, fluorescence spectroscopy, viscosity measurement in buffer solution of Tris-HCl（pH = 7.25）. All of the results indicated that the interaction of the complexe with ct-DNA is intercalation,the binding constant is 6.02×10^4 L/mol, and the binding spot is 1.07.

关 键 词：2 3-二(2-呋喃)喹喔啉化合物 ct—DNA 插入模式 

分 类 号：O69[理学—化学]