甲状旁腺激素构效关系的研究进展  

Research developments in parathyroid hormone

作　　者：王莹[1] 郄建坤[2] 程卯生[1] 刘克良[2] 

机构地区：[1]沈阳药科大学制药工程学院,沈阳110016 [2]军事医学科学院毒物药物研究所,北京100850

出　　处：《中国新药杂志》2007年第24期2017-2020,共4页Chinese Journal of New Drugs

摘　　要：甲状旁腺激素(PTH)是生物体内调节钙、磷代谢最为重要的肽类激素之一,其氨基端1-34片段具有全分子PTH与受体结合的能力及生物活性,被广泛用于研究PTH的结构与功能。PTH二级结构中富含α-螺旋,该螺旋结构在PTH与受体相互作用中起重要作用,其中羧基端负责与受体结合,氨基端负责生理活性。现从甲状旁腺激素的结构、与受体的相互作用和构效关系等角度出发,综述了甲状旁腺激素近年来的研究状况,为开发新型骨质疏松症治疗药物提供理论依据。Parathyroid hormone （PTH） is an important peptide hormone in regulating the calcium and phosphorus metabolism. Its N-extremity 1-34 fragment has the ability of binding with acceptor and biological activity which can substitute for entire molecular PTH, widely used in studying PTH structure and function. In the PTH second structure contains richly a-helix. This kind of structure affects the vital role when the PTH react with its receptor. The C-terminal is responsible for the acceptor union, the N-terminal is responsible for the biological activity. The molecule structure, receptor interaction and structure-activity relationship of PTH in recent years were reviewed in this article for discovering new therapeutics for the treatment of osteoporosis.

关 键 词：甲状旁腺激素 构效关系 钙磷代谢 骨质疏松症 

分 类 号：Q573[生物学—生物化学]